未经治疗的急性髓性白血病患者的肺囊虫肺炎的患病率和基因分型

Biology and Life Sciences Forum Pub Date : 2021-10-20 DOI:10.3390/blsf2021005003

V. Prete, G. Paterno, D. di Cave, L. Guarnera, R. Palmieri, L. Maurillo, F. Buccisano, A. Venditti, M. D. del Principe

{"title":"未经治疗的急性髓性白血病患者的肺囊虫肺炎的患病率和基因分型","authors":"V. Prete, G. Paterno, D. di Cave, L. Guarnera, R. Palmieri, L. Maurillo, F. Buccisano, A. Venditti, M. D. del Principe","doi":"10.3390/blsf2021005003","DOIUrl":null,"url":null,"abstract":"Pneumocystis jirovecii pneumonia (PJP) is an opportunistic infection affecting immunocompromised patients. Patients with acute myeloid leukemia (AML) are not considered at high risk of PJP, thus, prophylaxis is not recommended. Between 2010 and 2020 we retrospectively analyzed 251 AML patients. We performed molecular diagnosis and genotyping of Pneumocystis jirovecii in 67 bronchoalveolar lavage samples. Eleven cases of PJP were diagnosed, with a prevalence of 4.3%. Our study confirms that the most widespread genotype in Europe is genotype 1; in our patients, 70% presented with genotype 1 and 30% the genotype 3.","PeriodicalId":400770,"journal":{"name":"Biology and Life Sciences Forum","volume":"49 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prevalence and Genotyping of Pneumocystis jirovecii Pneumonia in Patients with Previously Untreated Acute Myeloid Leukemia\",\"authors\":\"V. Prete, G. Paterno, D. di Cave, L. Guarnera, R. Palmieri, L. Maurillo, F. Buccisano, A. Venditti, M. D. del Principe\",\"doi\":\"10.3390/blsf2021005003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Pneumocystis jirovecii pneumonia (PJP) is an opportunistic infection affecting immunocompromised patients. Patients with acute myeloid leukemia (AML) are not considered at high risk of PJP, thus, prophylaxis is not recommended. Between 2010 and 2020 we retrospectively analyzed 251 AML patients. We performed molecular diagnosis and genotyping of Pneumocystis jirovecii in 67 bronchoalveolar lavage samples. Eleven cases of PJP were diagnosed, with a prevalence of 4.3%. Our study confirms that the most widespread genotype in Europe is genotype 1; in our patients, 70% presented with genotype 1 and 30% the genotype 3.\",\"PeriodicalId\":400770,\"journal\":{\"name\":\"Biology and Life Sciences Forum\",\"volume\":\"49 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-10-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biology and Life Sciences Forum\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/blsf2021005003\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biology and Life Sciences Forum","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/blsf2021005003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

肺囊虫肺炎(PJP)是一种影响免疫功能低下患者的机会性感染。急性髓性白血病(AML)患者不被认为是PJP的高风险，因此不建议预防。2010年至2020年间，我们回顾性分析了251例AML患者。我们对67例支气管肺泡灌洗液标本进行了肺孢子虫的分子诊断和基因分型。确诊PJP 11例，患病率4.3%。我们的研究证实，在欧洲最广泛的基因型是基因1型;在我们的患者中，70%为基因1型，30%为基因3型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Prevalence and Genotyping of Pneumocystis jirovecii Pneumonia in Patients with Previously Untreated Acute Myeloid Leukemia

Pneumocystis jirovecii pneumonia (PJP) is an opportunistic infection affecting immunocompromised patients. Patients with acute myeloid leukemia (AML) are not considered at high risk of PJP, thus, prophylaxis is not recommended. Between 2010 and 2020 we retrospectively analyzed 251 AML patients. We performed molecular diagnosis and genotyping of Pneumocystis jirovecii in 67 bronchoalveolar lavage samples. Eleven cases of PJP were diagnosed, with a prevalence of 4.3%. Our study confirms that the most widespread genotype in Europe is genotype 1; in our patients, 70% presented with genotype 1 and 30% the genotype 3.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Biology and Life Sciences Forum

自引率

0.00%

发文量