{"title":"t细胞生长因子活化的外周血淋巴细胞中CD8+CD11b−细胞对胃癌患者抗肿瘤活性的抑制作用","authors":"T. Ebihara, N. Sakai, S. Koyama","doi":"10.1016/0277-5379(91)90439-K","DOIUrl":null,"url":null,"abstract":"<div><p>To confirm the phenotypic characteristics of lymphokine-activated suppressor (LAS)effector cells, we isolated CD8<sup>+</sup>CD11b<sup>−</sup> and CD8<sup>−</sup>CD11b<sup>−</sup> cells from T-cell growth factor (TCGF)-activated peripheral blood lymphocytes (PBL) in 7 patients with gastric carcinoma (4 non-resectable and 3 resectable carcinoma) and 3 healthy controls. Sorted CD8<sup>+</sup>CD11b<sup>−</sup> cells from 3 of the patients with non-resectable carcinoma and from 1 of the patients with resectable carcinoma showed LAS cell activity. However, the LAS cell activity could not be observed in CD8<sup>+</sup>CD11b<sup>−</sup> cells from healthy controls. In addition, a sorted CD8<sup>−</sup>CD11b<sup>−</sup> subset of cells from both cancer patients and control did not express any suppressive activity. These facts clearly show that the cell populations responsible for suppression of cell-mediated antitumour immunity reside within CD8<sup>+</sup>CD11b<sup>−</sup> T-cells, at least in patients with advanced carcinoma.</p></div>","PeriodicalId":11925,"journal":{"name":"European Journal of Cancer and Clinical Oncology","volume":"27 12","pages":"Pages 1654-1657"},"PeriodicalIF":0.0000,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0277-5379(91)90439-K","citationCount":"8","resultStr":"{\"title\":\"Suppression by sorted CD8+CD11b− cells from T-cell growth factor-activated peripheral blood lymphocytes on cytolytic activity against tumour in patients with gastric carcinoma\",\"authors\":\"T. Ebihara, N. Sakai, S. Koyama\",\"doi\":\"10.1016/0277-5379(91)90439-K\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>To confirm the phenotypic characteristics of lymphokine-activated suppressor (LAS)effector cells, we isolated CD8<sup>+</sup>CD11b<sup>−</sup> and CD8<sup>−</sup>CD11b<sup>−</sup> cells from T-cell growth factor (TCGF)-activated peripheral blood lymphocytes (PBL) in 7 patients with gastric carcinoma (4 non-resectable and 3 resectable carcinoma) and 3 healthy controls. Sorted CD8<sup>+</sup>CD11b<sup>−</sup> cells from 3 of the patients with non-resectable carcinoma and from 1 of the patients with resectable carcinoma showed LAS cell activity. However, the LAS cell activity could not be observed in CD8<sup>+</sup>CD11b<sup>−</sup> cells from healthy controls. In addition, a sorted CD8<sup>−</sup>CD11b<sup>−</sup> subset of cells from both cancer patients and control did not express any suppressive activity. These facts clearly show that the cell populations responsible for suppression of cell-mediated antitumour immunity reside within CD8<sup>+</sup>CD11b<sup>−</sup> T-cells, at least in patients with advanced carcinoma.</p></div>\",\"PeriodicalId\":11925,\"journal\":{\"name\":\"European Journal of Cancer and Clinical Oncology\",\"volume\":\"27 12\",\"pages\":\"Pages 1654-1657\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0277-5379(91)90439-K\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Cancer and Clinical Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/027753799190439K\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Cancer and Clinical Oncology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/027753799190439K","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Suppression by sorted CD8+CD11b− cells from T-cell growth factor-activated peripheral blood lymphocytes on cytolytic activity against tumour in patients with gastric carcinoma
To confirm the phenotypic characteristics of lymphokine-activated suppressor (LAS)effector cells, we isolated CD8+CD11b− and CD8−CD11b− cells from T-cell growth factor (TCGF)-activated peripheral blood lymphocytes (PBL) in 7 patients with gastric carcinoma (4 non-resectable and 3 resectable carcinoma) and 3 healthy controls. Sorted CD8+CD11b− cells from 3 of the patients with non-resectable carcinoma and from 1 of the patients with resectable carcinoma showed LAS cell activity. However, the LAS cell activity could not be observed in CD8+CD11b− cells from healthy controls. In addition, a sorted CD8−CD11b− subset of cells from both cancer patients and control did not express any suppressive activity. These facts clearly show that the cell populations responsible for suppression of cell-mediated antitumour immunity reside within CD8+CD11b− T-cells, at least in patients with advanced carcinoma.
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