Josef Wallner , Dieter Depisch , Martina Hopfner , Karin Haider , Jürgen Spona , Heinz Ludwig , Robert Pirker
{"title":"MDR1基因在原发性乳腺癌中的表达及预后影响因素","authors":"Josef Wallner , Dieter Depisch , Martina Hopfner , Karin Haider , Jürgen Spona , Heinz Ludwig , Robert Pirker","doi":"10.1016/0277-5379(91)90008-2","DOIUrl":null,"url":null,"abstract":"<div><p>To prospectively assess the role of the <em>MDR</em>1 gene in breast carcinomas, <em>MDR</em>1 RNA levels of breast carcinoma specimens were determined by slot blot analysis. In 59 evaluable patients with primary breast carcinomas, <em>MDR</em>1 RNA levels of the carcinomas were negative in 54%, low in 29% and high in 17% of the patients. No differences in age, menopause status, oestrogen and progesterone receptor levels, tumour size, lymph node involvement and c-<em>erb</em>B-2/<em>neu</em> gene expression were observed between <em>MDR</em>1 RNA negative patients and <em>MDR</em>1 RNA positive patients.</p></div>","PeriodicalId":11925,"journal":{"name":"European Journal of Cancer and Clinical Oncology","volume":"27 11","pages":"Pages 1352-1355"},"PeriodicalIF":0.0000,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0277-5379(91)90008-2","citationCount":"51","resultStr":"{\"title\":\"MDR1 gene expression and prognostic factors in primary breast carcinomas\",\"authors\":\"Josef Wallner , Dieter Depisch , Martina Hopfner , Karin Haider , Jürgen Spona , Heinz Ludwig , Robert Pirker\",\"doi\":\"10.1016/0277-5379(91)90008-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>To prospectively assess the role of the <em>MDR</em>1 gene in breast carcinomas, <em>MDR</em>1 RNA levels of breast carcinoma specimens were determined by slot blot analysis. In 59 evaluable patients with primary breast carcinomas, <em>MDR</em>1 RNA levels of the carcinomas were negative in 54%, low in 29% and high in 17% of the patients. No differences in age, menopause status, oestrogen and progesterone receptor levels, tumour size, lymph node involvement and c-<em>erb</em>B-2/<em>neu</em> gene expression were observed between <em>MDR</em>1 RNA negative patients and <em>MDR</em>1 RNA positive patients.</p></div>\",\"PeriodicalId\":11925,\"journal\":{\"name\":\"European Journal of Cancer and Clinical Oncology\",\"volume\":\"27 11\",\"pages\":\"Pages 1352-1355\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0277-5379(91)90008-2\",\"citationCount\":\"51\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Cancer and Clinical Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0277537991900082\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Cancer and Clinical Oncology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0277537991900082","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
MDR1 gene expression and prognostic factors in primary breast carcinomas
To prospectively assess the role of the MDR1 gene in breast carcinomas, MDR1 RNA levels of breast carcinoma specimens were determined by slot blot analysis. In 59 evaluable patients with primary breast carcinomas, MDR1 RNA levels of the carcinomas were negative in 54%, low in 29% and high in 17% of the patients. No differences in age, menopause status, oestrogen and progesterone receptor levels, tumour size, lymph node involvement and c-erbB-2/neu gene expression were observed between MDR1 RNA negative patients and MDR1 RNA positive patients.
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