复发/难治性卵巢癌所致恶性腹水的治疗:体内和体外使用干扰素-α或干扰素-α联合化疗

W.R. Bezwoda, T. Golombick, R. Dansey, J. Keeping
{"title":"复发/难治性卵巢癌所致恶性腹水的治疗:体内和体外使用干扰素-α或干扰素-α联合化疗","authors":"W.R. Bezwoda,&nbsp;T. Golombick,&nbsp;R. Dansey,&nbsp;J. Keeping","doi":"10.1016/0277-5379(91)90024-8","DOIUrl":null,"url":null,"abstract":"<div><p>Intraperitoneal treatment with interferon (IFN) for malignant ascites due to advanced ovarian carcinoma refractory to chemotherapy gave an objective response rate of 36% (<span><math><mtext>7</mtext><mtext>19</mtext></math></span> patients treated). <em>In vitro</em> studies demonstrated that cytotoxicity of peripheral blood monocytes/macrophages was stimulated by IFN. However, peritoneal exudate cells obtained after intraperitoneal treatment with interferon were not stimulated to kill autologous tumour cells. Clinical response was therefore most probably due to a direct inhibitory effect of IFN on growth of malignant cells rather than due to an immune modulatory effect. Using a newly established ovarian cancer cell line (UWOV1), synergy between the growth inhibitory/antitumour effects of IFN and cisplatin was demonstrated at clinically achievable concentrations of each agent. IFN plus cisplatin proved to be more effective than intraperitoneal cisplatin alone in control of peritoneal carcinomatosis. The response rate was <span><math><mtext>5</mtext><mtext>7</mtext></math></span> (77%) for combined modality therapy vs. <span><math><mtext>2</mtext><mtext>9</mtext></math></span> (22%) for intraperitoneal chemotherapy alone. Both <em>in vitro</em> and <em>in vivo</em> studies suggest a role for interperitoneal therapy for control of refractory ascites in ovarian cancer.</p></div>","PeriodicalId":11925,"journal":{"name":"European Journal of Cancer and Clinical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0277-5379(91)90024-8","citationCount":"15","resultStr":"{\"title\":\"Treatment of malignant ascites due to recurrent/refractory ovarian cancer: the use of interferon-α or interferon-α plus chemotherapy in vivo and in vitro\",\"authors\":\"W.R. Bezwoda,&nbsp;T. Golombick,&nbsp;R. Dansey,&nbsp;J. Keeping\",\"doi\":\"10.1016/0277-5379(91)90024-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Intraperitoneal treatment with interferon (IFN) for malignant ascites due to advanced ovarian carcinoma refractory to chemotherapy gave an objective response rate of 36% (<span><math><mtext>7</mtext><mtext>19</mtext></math></span> patients treated). <em>In vitro</em> studies demonstrated that cytotoxicity of peripheral blood monocytes/macrophages was stimulated by IFN. However, peritoneal exudate cells obtained after intraperitoneal treatment with interferon were not stimulated to kill autologous tumour cells. Clinical response was therefore most probably due to a direct inhibitory effect of IFN on growth of malignant cells rather than due to an immune modulatory effect. Using a newly established ovarian cancer cell line (UWOV1), synergy between the growth inhibitory/antitumour effects of IFN and cisplatin was demonstrated at clinically achievable concentrations of each agent. IFN plus cisplatin proved to be more effective than intraperitoneal cisplatin alone in control of peritoneal carcinomatosis. The response rate was <span><math><mtext>5</mtext><mtext>7</mtext></math></span> (77%) for combined modality therapy vs. <span><math><mtext>2</mtext><mtext>9</mtext></math></span> (22%) for intraperitoneal chemotherapy alone. Both <em>in vitro</em> and <em>in vivo</em> studies suggest a role for interperitoneal therapy for control of refractory ascites in ovarian cancer.</p></div>\",\"PeriodicalId\":11925,\"journal\":{\"name\":\"European Journal of Cancer and Clinical Oncology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0277-5379(91)90024-8\",\"citationCount\":\"15\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Cancer and Clinical Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0277537991900248\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Cancer and Clinical Oncology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0277537991900248","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 15

摘要

干扰素(IFN)腹腔内治疗化疗难治性晚期卵巢癌所致恶性腹水,客观有效率为36%(719例患者接受治疗)。体外研究表明,IFN可刺激外周血单核/巨噬细胞的细胞毒性。然而,腹腔内用干扰素治疗后获得的腹膜渗出细胞不能刺激杀死自体肿瘤细胞。因此,临床反应最有可能是由于IFN对恶性细胞生长的直接抑制作用,而不是由于免疫调节作用。使用新建立的卵巢癌细胞系(UWOV1),在临床可达到的浓度下,证明了IFN和顺铂的生长抑制/抗肿瘤作用之间的协同作用。IFN联合顺铂治疗腹膜癌的效果优于单用顺铂治疗腹膜癌。联合治疗的有效率为57%(77%),而单独腹腔化疗的有效率为29%(22%)。体外和体内研究都表明,腹膜间治疗对卵巢癌难治性腹水的控制具有重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatment of malignant ascites due to recurrent/refractory ovarian cancer: the use of interferon-α or interferon-α plus chemotherapy in vivo and in vitro

Intraperitoneal treatment with interferon (IFN) for malignant ascites due to advanced ovarian carcinoma refractory to chemotherapy gave an objective response rate of 36% (719 patients treated). In vitro studies demonstrated that cytotoxicity of peripheral blood monocytes/macrophages was stimulated by IFN. However, peritoneal exudate cells obtained after intraperitoneal treatment with interferon were not stimulated to kill autologous tumour cells. Clinical response was therefore most probably due to a direct inhibitory effect of IFN on growth of malignant cells rather than due to an immune modulatory effect. Using a newly established ovarian cancer cell line (UWOV1), synergy between the growth inhibitory/antitumour effects of IFN and cisplatin was demonstrated at clinically achievable concentrations of each agent. IFN plus cisplatin proved to be more effective than intraperitoneal cisplatin alone in control of peritoneal carcinomatosis. The response rate was 57 (77%) for combined modality therapy vs. 29 (22%) for intraperitoneal chemotherapy alone. Both in vitro and in vivo studies suggest a role for interperitoneal therapy for control of refractory ascites in ovarian cancer.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信