牛磺酸能保护病理性近视患者的视力吗?

Lina R Paez, Norma E Ávila Portillo
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引用次数: 0

摘要

牛磺酸是一种半必需的氨基磺酸,在视网膜中含量很高。它具有抗炎、抗氧化和神经调节特性,已被证明对特定的神经退行性疾病有益[1]。然而,其对高度近视及其并发症的影响尚不清楚。我们报告一例60岁的病理性近视女性,7年前,她的最佳矫正视力(BCVA)为20/200右眼(OD)和20/70左眼(OS),并被诊断为脉络膜新生血管膜(CNV) OS。她开始补充牛磺酸(每天1.5 g,持续14天),BCVA改善至20/100 OD。她继续每天服用500毫克。随后的事件包括4次afliberept OS注射,双眼白内障手术(AO),以及AO的周围视网膜光凝。最后的治疗引起了严重的炎症和视力的丧失。她接受皮质类固醇治疗,但两周后由于缺乏改善,牛磺酸剂量增加到1 g/天。三周后,她的BCVA从数手指降至20/60 OS,炎症得到控制。在连续摄入牛磺酸7年后,她的CNV OS一直处于不活跃状态,BCVA在去年稳定甚至有所改善,分别从20/45 OD和20/80 OS提高到20/25 OD和20/60 OS。与此同时,她偏头痛的强度和频率也有所下降。本病例报告为补充牛磺酸在高度近视、视网膜变性和病理性近视中的潜在应用提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Does Taurine Preserve Visual Acuity in a Patient with Pathologic Myopia?
Taurine, a semi-essential amino sulfonic acid, is present in high amounts in the retina. It has anti-inflammatory, antioxidant, and neuromodulatory properties which have shown to be beneficial for specific neurodegenerative conditions [1]. However, its effects on high myopia or its complications are unknown. We report the case of a 60-year-old woman with pathological myopia, who 7 years ago, presented a best corrected visual acuity (BCVA) of 20/200 right eye (OD) and 20/70 left eye (OS), and was diagnosed with a choroidal neovascular membrane (CNV) OS. She initiated taurine supplementation (1.5 g/ daily for 14 days) and improved to a BCVA of 20/100 OD. She continued taking 500 mg/daily. Subsequent events included 4 injections of Aflibercept OS, cataract surgery in both eyes (AO), and peripheral retinal photocoagulation in AO. This last treatment induced a severe inflammation and loss of visual acuity OS. She was treated with corticosteroids, but after two weeks due to lack of improvement, the taurine dose was increased to 1 g/day. Three weeks after, her BCVA went from counting fingers to 20/60 OS, and her inflammation was controlled. After 7 years of continuous taurine intake, her CNV OS has remained inactive, her BCVA was stable and even improved in the last year from 20/45 OD and 20/80 OS to 20/25 OD and 20/60 OS, respectively. At the same time, her migraines decreased in intensity and frequency. This case report brings a new light towards the potential use of taurine supplementation in high myopia, retinal degeneration, and pathologic myopia.
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