破坏内侧半月板以诱发家猪创伤后骨关节炎

Journal of Cartilage & Joint Preservation Pub Date : 2023-12-01 DOI:10.1016/j.jcjp.2023.100139

Jacqueline M. Chevalier , Garett B. Pearson , Nicole Nixon , Carl R. Flannery , Luis Campoy , Lisa A. Fortier

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引用次数: 0

摘要

导言：创伤后骨关节炎（PTOA）是在创伤性关节损伤后发生的。用于研究创伤后骨关节炎的发展和治疗的一个模型系统是 Glasson 等人首次在迷你猪身上描述的内侧半月板失稳（DMM）。与家猪相比，迷你猪的可用性较差，价格较高，而且滑液取样受到限制，从而限制了骨关节炎生物标志物的可用性。以下技术说明详细介绍了将约克夏猪用作大型动物 PTOA 模型的步骤和动物福利策略。方法以下技术说明详细介绍了将约克夏猪作为大型动物 PTOA 模型进行围手术期隐神经阻断、DMM 和后续术后管理的步骤。结果术后 4 周，根据死后关节解剖，所有猪均出现轻中度 PTOA。

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Destabilization of the medial meniscus to induce post-traumatic osteoarthritis in domestic pigs

Introduction

Post-traumatic osteoarthritis (PTOA) develops following traumatic articular insult. One model system used to study the progression and treatment of PTOA is the destabilization of the medial meniscus (DMM) as first described by Glasson et al performed in mini-pigs. Miniature pigs are less available, more expensive, and have synovial fluid sampling limitations, limiting the availability of osteoarthritis biomarkers compared to domestic pigs.

Objectives

The following technical note details stepwise procedures and animal welfare strategies for the use of Yorkshire pigs as a large animal PTOA model.

Methods

The following technical note details stepwise procedures to perform peroperative saphenous nerve block, DMM, and subsequent postoperative management in Yorkshire pigs as a large animal PTOA model.