几内亚科纳克里抗逆转录病毒治疗患者HIV病毒载量病毒学抑制相关因素

A. Camara, P. Diallo, M. Diallo, Talla Nioké, Adama Cissé, M. Sylla, Gobounet Lamah, M. Diakité, A. Bah, M. Keita, A. Keita, Mamoudou N. Conde, K. Kourouma, R. Camara, Y. Koita, Fode Bangaly Magassouba, A. Camara, Abdoulaye Touré
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摘要

背景:病毒载量已成为评估艾滋病毒/艾滋病感染者抗逆转录病毒治疗(ART)的不可或缺的工具。本研究旨在评估几内亚艾滋病毒/艾滋病感染者接受抗逆转录病毒治疗的病毒学抑制情况。方法:这是一项为期三年多的描述性横断面研究,涉及在科纳克里不同地点接受治疗的成年艾滋病毒阳性患者。共收集了9815份病毒载量数据。采用Generic Biocentric技术定量病毒载量,检测阈值设置为350拷贝/ml。采用R软件R4.0.3进行统计分析。结果对国家公共卫生实验室收集的9815份病毒载量数据进行了分析。样本以女性为主(72%),平均年龄29岁[29,39]。其中,接受抗逆转录病毒治疗的艾滋病毒阳性患者中有6706人(68%)的病毒载量得到抑制。单变量分析显示,女性VL抑制的可能性要高出22% (p值<0.001)。此外,所有接受治疗的hiv阳性患者实现病毒载量抑制的机会与治疗时间有关。结论本研究结果显示病毒载量抑制大于68%。抗逆转录病毒治疗时间长短、女性、PLHIV患者年龄较大均有利于VL的抑制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Factors Associated With Virological Suppression of HIV Viral Load in Patients on Antiretroviral Therapy in Conakry, Guinea
BackgroundThe viral load has become an indispensable tool in evaluating antiretroviral therapy (ART) in people living with HIV / AIDS. This study aimed to assess virological suppression among in people living with HIV / AIDS on antiretroviral therapy in Guinea.MethodsThis was a descriptive cross-sectional study of more than three years that involved adult HIV-positive patients treated in different sites in Conakry. A total of 9815 viral load data were collected. The viral load was quantified by the Generic Biocentric technique and the detection threshold set at 350 copies/ml. Statistical analyses were performed by R software version R4.0.3..ResultsA total of 9815 viral load data collected at the national public health laboratory were analysed. The sample was dominated by women (72%), with an average age of 29 [29, 39]. Of these, 6,706 (68%) of HIV-positive people on ART had viral load suppression. The univaried analysis showed that women were 22% more likely to have VL suppression (p-value <0.001) moreover, the chance for all HIV-positive people on treatment to achieve viral load suppression was related to the length of treatment.Conclusionthe results of this study show viral load suppression greater than 68%. The length of antiretroviral therapy, female gender, and advancing age of PLHIV were all favourable to VL suppression.
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