胰凝乳酶催化片段偶联合成gnrh类似物。

Biomedica biochimica acta Pub Date : 1991-01-01

A Hänsicke, E Krause, M Bienert, M Schmidt, S Kobert, V Schellenberger, H D Jakubke, K D Kaufmann

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引用次数: 0

摘要

通过胰凝乳酶催化3 + 7片段偶联合成D-Xaa6-GnRH类似物(Xaa: Ala, Nal1)， Phe, Ser(tBu)， Trp)，氨基组分转化率为90.3 ~ 97.4%。对于D-Phe6-GnRH，该方法已扩大到生产水平。

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Chymotrypsin-catalyzed fragment coupling synthesis of GnRH-analogs.

D-Xaa6-GnRH analogs (Xaa: Ala, Nal1), Phe, Ser(tBu), Trp) were prepared by chymotrypsin catalyzed 3 + 7 fragment coupling synthesis with conversion rates of the amino component in the range from 90.3 to 97.4%. For D-Phe6-GnRH the method was scaled up to production level.

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Biomedica biochimica acta

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