{"title":"[用于确定表面活性剂制剂有效性的标准化体内模型]。","authors":"A Oddoy","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The premature rabbit neonate of the 27th day of gestation is a useful model for testing intratracheally applied surfactant preparations. Immediately after application of an effective surfactant the thorax lung compliance--as the decisive measure--rises significantly. We could exclude effects of the applied fluid per se. The most reliable result about the efficiency of a surfactant preparation is given by the cumulative dose response relationship. In a semilogarithmic system there is a linear relationship between the surfactant dose (25-200 mg phospholipids per kg b.w.) and the thorax-lung-compliance.</p>","PeriodicalId":76840,"journal":{"name":"Zeitschrift fur Erkrankungen der Atmungsorgane","volume":"177 3","pages":"135-43"},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[A standardized in vivo model for determining the effectiveness of surfactant preparations].\",\"authors\":\"A Oddoy\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The premature rabbit neonate of the 27th day of gestation is a useful model for testing intratracheally applied surfactant preparations. Immediately after application of an effective surfactant the thorax lung compliance--as the decisive measure--rises significantly. We could exclude effects of the applied fluid per se. The most reliable result about the efficiency of a surfactant preparation is given by the cumulative dose response relationship. In a semilogarithmic system there is a linear relationship between the surfactant dose (25-200 mg phospholipids per kg b.w.) and the thorax-lung-compliance.</p>\",\"PeriodicalId\":76840,\"journal\":{\"name\":\"Zeitschrift fur Erkrankungen der Atmungsorgane\",\"volume\":\"177 3\",\"pages\":\"135-43\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift fur Erkrankungen der Atmungsorgane\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Erkrankungen der Atmungsorgane","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[A standardized in vivo model for determining the effectiveness of surfactant preparations].
The premature rabbit neonate of the 27th day of gestation is a useful model for testing intratracheally applied surfactant preparations. Immediately after application of an effective surfactant the thorax lung compliance--as the decisive measure--rises significantly. We could exclude effects of the applied fluid per se. The most reliable result about the efficiency of a surfactant preparation is given by the cumulative dose response relationship. In a semilogarithmic system there is a linear relationship between the surfactant dose (25-200 mg phospholipids per kg b.w.) and the thorax-lung-compliance.