[铂(II)与氨和环烷基胺混合配合物的生长抑制活性]。

E I Bystrova, V B Ivanov, P A Chel'tsov
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引用次数: 0

摘要

研究了混合半酪氨酸和3-、4-、5-、6-名名环烷基胺或取代的2-、3-、4-甲基和4-羟基环己胺,以及类似的含有丙二酸、羟丙二酸、琥珀酸和苹果酸阴离子的羧化配合物对玉米芽根生长的影响。非取代环烷基胺配合物具有最显著的细胞抑制活性。取代环己胺配合物的活性低于其非取代类似物以及其他环取代物尺寸较小的配合物。与氯配合物相比,羧酸配合物的细胞抑制活性通常在高10倍的浓度下表现出来,不仅取决于环烷基胺的大小,还取决于酸配体的性质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The growth-inhibiting activity of mixed complexes of platinum(II) with ammonia and cycloalkylamines].

The effect was studied of mixed cys- and 3-, 4-, 5-, 6-nomial cycloalkylamines or substituted 2-, 3-, 4-methyl- and 4-hydroxycyclohexylamines as well as similar carboxylatocomplexes containing anions of malonic hydroxymalonic, succinic and malic acids on the growth of corn sprout roots. Complexes with non-substituted cycloalkylamines possessed the most pronounced cytostatic activity. Complexes with substituted cyclohexylamines were less active than their non-substituted analogue as well as other complexes with lesser size of cyclic substitute. The cytostatic activity of carboxylatocomplexes, as compared to that of chlorocomplexes, generally manifested itself at ten times higher concentraiton and depended not only on the size of cycloalkylamine but also on the nature of acidoligand.

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