Association between Proton Pump Inhibitors Use and Spontaneous ‎Bacterial Peritonitis Development in Egyptian Cirrhotic Patients with Ascites‎

their indication. Results: Out of 209 cirrhotic patients with ascites, SBP was detected in 34.9% of patients whether they were on PPIs or not. SBP patients had a significant higher use of PPIs therapy (72.6%) than the non-SBP patients (26.5%) ( P< 0.001). However, there was no statistical significant difference regarding type of PPIs or indications of use ( P> 0.05). Conclusion: The rate of PPIs use was higher in SBP patients than in patients without SBP. There were no differences regarding PPIs types or indications of use between both groups. Thus, PPIs therapy should be judiciously used and only when indicated in patients with liver cirrhosis and ascites.