Synchronized Control for Circadian Rhythm Based on the Central Clock Model of Drosophila

Circadian rhythm governed by an oscillating set of genes called the central clock has become an important concern in biology, and it is said that to restore an altered rhythm is a goal of cancer therapy beyond the destruction of tumor cells. In this paper, we study the central clock model of drosophila, which is a nonlinear oscillator model. We propose a close-loop control based on flatness-based adaptive control, an open-loop control, to achieve circadian rhythm restoration