啮齿类动物尿液中金属内肽酶的活性。

Biomedica biochimica acta Pub Date : 1991-01-01

R J Beynon, A V Flannery, G C Macadam

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引用次数: 0

摘要

小鼠和大鼠的刷状缘膜含有一种磷酸不敏感的金属蛋白酶，meprin(中性内肽酶-2;NEP-2)。梅普林的作用尚不清楚，但我们已经证明，这些物种的尿液含有胰岛素B链降解活性，这是由于磷酰胺不敏感的金属内肽酶。根据酶学和免疫学标准，这种活性很可能是由于meprin，并引入了这种酶可能在泌尿功能中起作用的可能性。

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Metalloendopeptidase activity in urine of rodents.

The brush border membrane of mice and rats contains a phosphoramidon-insensitive metalloproteinase, meprin (neutral endopeptidase-2; NEP-2). The role of meprin is unknown, but we have shown that urine from these species contains insulin B chain degrading activity that is due to a phosphoramidon-insensitive metalloendopeptidase. By enzymic and immunological criteria, it is likely that this activity is due to meprin, and introduces the possibility that this enzyme may have a role in urinary function.

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Biomedica biochimica acta

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