Antioxidants Status in Acute Lymphoblastic Leukemic Patients

ALL is the most common form of childhood cancer. Sufferers are treated with chemotherapy, which is asso- ciated with the production of free radicals. The aim of this study was to investigate the oxidative stress markers and some antioxidants status among Acute Lymphoblastic Leukemia patients. This study included 40 children newly diagnosed ALL before chemotherapy (mean age, 8.2 ±2) compared to 20 healthy controls (mean age, 7.6 ±1.4). The same of 40 patients of ALL undergoing chemotherapy treatment for 3 months. Oxidative stress, blood antioxidants status, kidney and liver pro- files were measured in all groups. Our results showed that Antioxidants levels and Hb were significant decreased in ALL patients (P < 0.05) compared to control group, then antioxidants levels were more significant decreasing after ALL patients undergoing chemotherapy. In contrast MDA, 8dG, leukocytes count and Lymphoblast were significant increased (P < 0.05) compared to control group. Also, Urea and creatinine levels were found no significant difference between different groups, there was mild increase after chemotherapy but not significant. On other hand, ALT and AST were found no significant difference between healthy control and ALL patients. But their levels were found statistically significant to be increased in ALL patients after chemotherapy compared to before chemotherapy. In. conclusion, there are possible link between de- creased antioxidants and increased levels of cells alterations due to oxidative damage in ALL, and this appear to be asso- ciated with complications of treatment.