人体DBS电极的力学分析

H. Draz, Eslam Elmitwalli, Mirna Soliman, S. Gabran, Mohamed Basha, H. Mostafa, M. Abu-Elyazeed, Amal Zaki
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引用次数: 0

摘要

脑深部电刺激(DBS)电极已被证明是有效的治疗神经相关疾病的啮齿动物。这些装置成功地扩展到人类神经治疗领域。存在许多不同的电极。然而,目前还没有定量的排序标准来对各种DBS电极进行有意义的比较,以帮助设计人员。本文提出了一种用于DBS电极的新型性能图(FOM)。所提出的优化性能考虑了力学分析的安全系数和某些材料的估计制造成本。FOM用于对几种DBS电极设计进行排序。对几种电极布局进行了有限元模型分析。有限元分析显示了不同设计参数对电极力学性能的影响。这些参数包括电极尺寸、几何形状和材料。从不同的角度对电极的力学分析进行了评价,包括线性屈曲分析、轴向载荷和剪切载荷下的稳态分析。计算了几种不同材料(脆性材料和延性材料)的安全系数。给出了各种电极原型的有限元力学分析结果,为不同电极的设计和材料的选择提供了指导。还介绍了一种建议的制造工艺以及估计的制造成本。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mechanical Analysis of Human DBS Electrodes
Deep brain stimulation (DBS) electrodes have been proved to be effective in treating neural related diseases in rodents. These devices were successfully extended to the field of human neuro therapy. Many different electrodes exist. However, no quantitative ranking criterion is available to allow meaningful comparison of the various DBS electrodes to aid the designer.This paper presents a novel Figure of Merit (FOM) dedicated to DBS electrodes. The proposed optimization performance takes into account safety factors of mechanical analysis and the estimated fabrication cost of some materials. The FOM is used to rank several DBS electrode designs.Finite Element Models (FEM) analysis for several electrode layouts are conducted. FEM shows the effects of different design parameters on the electrode mechanical performance. These parameters include electrode dimensions, geometry, and materials. The electrodes mechanical analysis is evaluated from different points of view including: linear buckling analysis, stationary analysis with axial and shear loading. The safety factors are calculated for several designs with different materials (brittle and ductile materials). The results obtained from FEM mechanical analysis for the various electrodes prototypes are presented, which provide guidelines for different electrode designs and material choice. A proposed fabrication process along with an estimated fabrication cost is also introduced.
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