The Peak of Cytochrome-c (Cyt-c) Gene Expression in Inflammatory Stage after Amputation of Digit Tip Mice (Mus musculus)

: The complexity of the tissue regeneration process requires the activity of cells and energy. The energy obtained from cellular respiration processes. The cellular respiration involves the enzyme has a role transfer an electron. Cytochrome-c (Cyt-c) is an enzyme in the mitochondria inner membrane that has a role in cell respiration and stimulates apoptosis cells. We studied the Cyt-c gene expression in inflammatory phase of tissue regeneration of digit tip mice ( Mus musculus ) after amputation to analyze a role in tissue regeneration. The result of the Cyt-c gene expression reached a peak on day 3. It showed that the tissue regeneration process needs high energy and involves cell apoptosis to stimulate regeneration. The result of ANOVA homogeneity test of Cyt-c gene expression differentt significantly for each growth day (p <0.05).