成纤维细胞生长因子8在不同癌症中的作用

Swati Ranjan, A. Saini, S. Yadav
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引用次数: 0

摘要

成纤维细胞生长因子8 (FGF8)是FGF家族的一种分泌蛋白,在发育早期高度表达。FGF8及其异构体的早期表达对生物体的正常发育至关重要,而它们在成年期的表达仅限于类固醇激素靶向组织。有趣的是,FGF8的差异表达与包括乳腺癌、前列腺癌和卵巢癌在内的各种癌症的进展有关。具体来说,在妇科癌症中,FGF8的表达受类固醇激素调节。FGF8亚型,即FGF8a、FGF8b、FGF8e和FGF8f通过MAP/RAS激酶、AKT/PI3和PCLγ三种主要信号通路,在不同癌症中通过不同的成纤维细胞生长因子受体起作用。这篇简短的综述文章讨论了FGF-8的结构和功能,以及它在不同癌症中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of fibroblast growth factor 8 in different cancers
Fibroblast growth factor 8 (FGF8), a secretory protein of the FGF family, is highly expressed during early developmental stages. The early-stage expression of FGF8 and its isoforms is crucial for the normal development of organisms, while their expressions in adulthood are limited to the steroid hormone-targeting tissues. Interestingly, differential expression of FGF8 has been associated with the progression of various cancer types including breast, prostate, and ovarian cancers. Specifically, in gynecological cancers, the expression of FGF8 is regulated by steroid hormones. FGF8 isoforms, that is, FGF8a, FGF8b, FGF8e, and FGF8f act through different fibroblast growth factor receptors in different cancers through three main signaling pathways – MAP/RAS kinase, AKT/PI3, and PCLγ. This short review article discusses the structure and functions of FGF-8, along with its role in different cancers.
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