Management of Large Periapical Lesion of Endodontic Origin with the Combination of Second Generation Platelet Extract and Xenograft

Periapical inflammatory lesion is the local response of bone around the apex of tooth that develops after the necrosis of the pulp tissue or substantial periodontal disease. Periapical surgery aims to remove periapical pathology to achieve wound healing and regeneration of bone and periodontal tissue. The purpose of this case report is to through a light on use of platelet rich fibrin and bone graft in the treatment of large periapical lesion. Platelet rich fibrin (PRF) is a magnificent tissue engineering product and has gained substantial popularity due to its promising results in wound healing bone induction. Bone graft used in both cases in the present case report was xenograft which is similar to human cancellous bone and is known to have osteoinductive as well as osteoconductive properties. Objectives: To remove infected, inflamed, necrotic and granulation tissues. To disinfect and decontaminate the peri-apical field. To achieve superior and rapidly progressive healing in peri- apical region by regenerative surgical approach using second generation Platelet extract and Xenograft.