Maite Nogales-Garcia , Naiara Parraza Diez , Andoni Vargas Axpe , Rafael Velasco Garcia , Ane Larrabeiti-Etxebarria , Ignacio Roy Lopez-Cano , Inmaculada Atrio Alvarez , Asier Lopez de Arcaute Trincado , Eva María Fernandez Lopez de Vicuña , Ester Saez de Adana Arroniz , Carlos Martínez Martínez , Joseba Portu Zapirain
{"title":"在惩教机构消除丙型肝炎病毒：18 年的经验","authors":"Maite Nogales-Garcia , Naiara Parraza Diez , Andoni Vargas Axpe , Rafael Velasco Garcia , Ane Larrabeiti-Etxebarria , Ignacio Roy Lopez-Cano , Inmaculada Atrio Alvarez , Asier Lopez de Arcaute Trincado , Eva María Fernandez Lopez de Vicuña , Ester Saez de Adana Arroniz , Carlos Martínez Martínez , Joseba Portu Zapirain","doi":"10.1016/j.eimc.2023.01.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Despite the decrease of hepatitis C in Spanish prisons in the last years, it still remains a reservoir for infection. The aim of this work is to analyze the characteristics of these patients and the response to antiviral treatment over the last 18 years.</p></div><div><h3>Methods</h3><p>Retrospective observational study in inmates of Araba penitentiary center diagnosed with HCV infection between 2002 and 2020.</p><p>A descriptive analysis of patient characteristics and the response to the 3 antiviral treatment modalities was performed: peg-interferon and ribavirin, peg-interferon, ribavirin and a first-generation protease inhibitor and different combinations of direct-acting antivirals.</p></div><div><h3>Results</h3><p>A total of 248 antiviral treatments were prescribed. Treatment response rate up to 2015 was 65% and 93,7% after that year. Interferon non-responders were the main cause of non-response to treatment in periods 1 and 2 (40-50%). Conversely, in period 3 <em>viral breakthroug</em>h (67%) was the main culprit.</p></div><div><h3>Conclusion</h3><p>After 18 years, active hepatitis C infection in prison inmates has resolved with treatment according to clinical criteria. Therefore, the stay in prison may represent an opportunity to reduce the reservoir of the disease in the community, together with continued health care for those released from prison.</p></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"42 5","pages":"Pages 236-241"},"PeriodicalIF":2.6000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Eliminación del virus de la hepatitis C en un centro penitenciario: una experiencia de 18 años\",\"authors\":\"Maite Nogales-Garcia , Naiara Parraza Diez , Andoni Vargas Axpe , Rafael Velasco Garcia , Ane Larrabeiti-Etxebarria , Ignacio Roy Lopez-Cano , Inmaculada Atrio Alvarez , Asier Lopez de Arcaute Trincado , Eva María Fernandez Lopez de Vicuña , Ester Saez de Adana Arroniz , Carlos Martínez Martínez , Joseba Portu Zapirain\",\"doi\":\"10.1016/j.eimc.2023.01.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Despite the decrease of hepatitis C in Spanish prisons in the last years, it still remains a reservoir for infection. The aim of this work is to analyze the characteristics of these patients and the response to antiviral treatment over the last 18 years.</p></div><div><h3>Methods</h3><p>Retrospective observational study in inmates of Araba penitentiary center diagnosed with HCV infection between 2002 and 2020.</p><p>A descriptive analysis of patient characteristics and the response to the 3 antiviral treatment modalities was performed: peg-interferon and ribavirin, peg-interferon, ribavirin and a first-generation protease inhibitor and different combinations of direct-acting antivirals.</p></div><div><h3>Results</h3><p>A total of 248 antiviral treatments were prescribed. Treatment response rate up to 2015 was 65% and 93,7% after that year. Interferon non-responders were the main cause of non-response to treatment in periods 1 and 2 (40-50%). Conversely, in period 3 <em>viral breakthroug</em>h (67%) was the main culprit.</p></div><div><h3>Conclusion</h3><p>After 18 years, active hepatitis C infection in prison inmates has resolved with treatment according to clinical criteria. Therefore, the stay in prison may represent an opportunity to reduce the reservoir of the disease in the community, together with continued health care for those released from prison.</p></div>\",\"PeriodicalId\":11608,\"journal\":{\"name\":\"Enfermedades infecciosas y microbiologia clinica\",\"volume\":\"42 5\",\"pages\":\"Pages 236-241\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Enfermedades infecciosas y microbiologia clinica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0213005X23000162\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Enfermedades infecciosas y microbiologia clinica","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0213005X23000162","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Eliminación del virus de la hepatitis C en un centro penitenciario: una experiencia de 18 años
Introduction
Despite the decrease of hepatitis C in Spanish prisons in the last years, it still remains a reservoir for infection. The aim of this work is to analyze the characteristics of these patients and the response to antiviral treatment over the last 18 years.
Methods
Retrospective observational study in inmates of Araba penitentiary center diagnosed with HCV infection between 2002 and 2020.
A descriptive analysis of patient characteristics and the response to the 3 antiviral treatment modalities was performed: peg-interferon and ribavirin, peg-interferon, ribavirin and a first-generation protease inhibitor and different combinations of direct-acting antivirals.
Results
A total of 248 antiviral treatments were prescribed. Treatment response rate up to 2015 was 65% and 93,7% after that year. Interferon non-responders were the main cause of non-response to treatment in periods 1 and 2 (40-50%). Conversely, in period 3 viral breakthrough (67%) was the main culprit.
Conclusion
After 18 years, active hepatitis C infection in prison inmates has resolved with treatment according to clinical criteria. Therefore, the stay in prison may represent an opportunity to reduce the reservoir of the disease in the community, together with continued health care for those released from prison.
期刊介绍：
Hoy está universalmente reconocida la renovada y creciente importancia de la patología infecciosa: aparición de nuevos agentes patógenos, de cepas resistentes, de procesos con expresión clínica hasta ahora desconocida, de cuadros de una gran complejidad. Paralelamente, la Microbiología y la Infectología Clínicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patología infecciosa. Enfermedades Infecciosas y Microbiología Clínica es la Publicación Oficial de la Sociedad Española SEIMC. Cumple con la garantía científica de esta Sociedad, la doble función de difundir trabajos de investigación, tanto clínicos como microbiológicos, referidos a la patología infecciosa, y contribuye a la formación continuada de los interesados en aquella patología mediante artículos orientados a ese fin y elaborados por autores de la mayor calificación invitados por la revista.
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