基于Zr-Fc MOF纳米片的代谢物检测质谱平台

2022 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) Pub Date : 2022-08-08 DOI:10.1109/3M-NANO56083.2022.9941509

Xiaoyu Xu, Yuxing Zhang, Haiyang Su, Yuning Wang, Kun Qian

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引用次数: 0

摘要

建立了基于Zr-Fc金属有机骨架(MOF)纳米片的激光解吸/电离质谱(LDI MS)检测代谢物的新平台。采用自下而上的方法合成了Zr-Fc超薄MOF纳米片。此外，通过优化条件，Zr-Fc MOF纳米片在无背景干扰的情况下表现出良好的LDI质谱基质性能。基于Zr-Fc MOF纳米片的LDI质谱平台已成功应用于检测多种高信号强度(~ 105)的氨基酸，在疾病诊断和评价的临床代谢分析中具有潜在价值。

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Zr-Fc MOF Nanosheets Based Mass Spectrometry Platform for Metabolites Detection

Novel Zr-Fc metal-organic framework (MOF) nanosheets based laser desorption/ionization mass spectrometry (LDI MS) platform has been developed for metabolites detection. The ultrathin Zr-Fc MOF nanosheets was synthesized using the bottom-up method. Furthermore, by optimizing the conditions, Zr-Fc MOF nanosheets exhibited excellent performance as an LDI MS matrix without background interference. The Zr-Fc MOF nanosheets based LDI MS platform has been successfully applied to detect various amino acids with high signal intensity (~ 105), which presents potential values in clinical metabolic analysis for disease diagnosis and evaluation.

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2022 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)

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