干扰素在肾细胞癌中的应用

Hyman B. Muss
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引用次数: 9

摘要

转移性肾细胞癌仍然是一种无法治愈的疾病,目前的治疗方式只能为一小部分患者提供主要的缓解。由于治疗是姑息性的,治疗的选择和类型必须仔细考虑,并与患者的愿望相协调。在可能的情况下,应该让患者参与临床试验。对于选择黄体酮治疗的患者,干扰素(IFN)或其他生物反应调节剂可以在黄体酮失败时进行治疗。那些肿瘤进展缓慢并维持高生活质量的患者可以在不继续黄体酮治疗的情况下观察。虽然预处理特征可以预测对生物制剂的反应,但没有预处理特征可以阻止单个患者进行IFN治疗试验。高剂量的白细胞介素-2 (IL-2)、IL-2/淋巴细胞活化杀伤细胞或IL-2/IFN是否优于单独使用IFN尚不确定,但目前正在进行的临床试验应有助于解决这些问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The use of interferon in renal cell carcinoma

Metastatic renal cell carcinoma remains an incurable disease and current modalities can only offer major palliation to a small percentage of patients. Since treatment is palliative, choice and type of therapy must be carefully considered and reconciled with patient desires. When possible, patients should be offered participation in a clinical trial. For patients choosing progestin therapy, treatment with interferon (IFN) or other biological response modifiers can be instituted at the time of progestin failure. Those patients who have slow tumour progression and maintain a high quality of life can be observed without continued progestin therapy. Although pretreatment characteristics predict response to biologicals, no pretreatment characteristic should preclude an individual patient from a trial of IFN therapy. Whether high-dose interleukin-2 (IL-2), IL-2/lymphocyte-activated killer cells, or IL-2/IFN are superior to IFN alone is uncertain, but clinical trials currently underway should help resolve these issues.

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