Current and promising methods of idiopathic male infertility treatment

For a significant number of couples around the world, male infertility is a serious ordeal. The truth is that this is also a major clinical challenge for the andrologist – up to 50 % of men with infertility have no identifiable etiology and there is no effective, available evidence-based treatment. For a long time, antioxidant supplements have been used as empiric therapy, but there is still no conclusive evidence that fertility and live birth rates actually improve after this approach has been used. This review is an attempt to summarize current and prospective treatments for idiopathic male infertility. Particular attention is paid to regulatory peptides as promising candidates for improving male fertility.