iii类抗心律失常药物对老年阵发性心房颤动患者疗效的比较评价

Rybakova T.A., Stolyarov V.V., Bataev Kh.M.
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引用次数: 0

摘要

摘要本文介绍了基于心率变异性和每隔3个月检查患者1年的预防性抗心律失常单药治疗索他己醛和可达酮的效果。研究心率变异性指标的相关性是毋庸置疑的。该程序的简单性和非侵入性决定了其越来越多的使用。研究结果表明,在已有阵发性房颤的患者中,以及在对照组中,房颤发作的发生机制都得到了证明,在对照组中,该疾病的发病记录是研究的结果。众所周知,随着年龄的增长,心血管系统疾病的增加,包括心房颤动。老年患者占了大部分。因此,根据心率变异性指标合理选择抗心律失常治疗有助于降低本组患者的发病率。在以III类抗心律失常药物代表sotahexal和cordarone为例研究抗心律失常治疗的有效性时,发现在研究1年结束时,sotahexal和cordarone单药治疗的有效性分别为74%和71%。接受索他己醛治疗1年后患者心率变异性指标间无显著差异,且在治疗初期,副交感神经系统的张力指标优于接受柯达酮治疗的患者,且张力与初始时呈下降趋势。在接受柯达酮治疗的患者中,一年后,与基线指标相比,植物平衡向交感张力转变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COMPARATIVE EVALUATION OF THE EFFECTIVENESS OF CLASS III ANTIARRHYTHMIC DRUGS IN ELDERLY PATIENTS WITH PAROXYSMAL ATRIAL FIBRILLATION
Abstract. The article presents the results of the effectiveness of preventive antiarrhythmic monotherapy with sotahexal and cordarone based on heart rate variability and examination of patients at intervals of every 3 months for one year. The relevance of studying heart rate variability indicators is beyond doubt. The simplicity and non-invasiveness of this procedure dictates its increasing use. As a result of the study, the mechanism of occurrence of paroxysms of atrial fibrillation was shown both in patients with the existing paroxysmal form of atrial fibrillation, and in comparison, groups, where the debuts of this disease were recorded as a result of the study. It is known that with age there is an increase in diseases of the cardiovascular system, including atrial fibrillation. Elderly patients make up the bulk. Therefore, properly selected antiarrhythmic therapy based on heart rate variability indicators can help reduce morbidity in this group of patients. When studying the effectiveness of antiarrhythmic therapy on the example of representatives of the III class of antiarrhythmic drugs sotahexal and cordarone, it was found that the effectiveness of monotherapy with sotahexal and cordarone by the end of 1 year of the study was 74 and 71%, respectively. Indicators of heart rate variability in patients receiving sotahexal after 1 year did not significantly differ from each other, and at the initial stage of treatment, indicators characterizing the tone of the parasympathetic nervous system prevailed over the same indicators of patients receiving cordarone, over the tone differed from the initial ones in the downward direction. In patients receiving cordarone, a year later, there was a shift in the vegetative balance towards sympathicotonia compared with baseline indicators.
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