印度恰蒂斯加尔邦三个部落种群的基因组多样性研究

Pankaj Kumar Temunkar, B. Tiwary, M. Mitra
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引用次数: 0

摘要

恰蒂斯加尔邦拥有多样化的语言和民族部落人口,是人类基因组多样性研究的热点。DNA水平上的个体变异遗传分析被广泛用于研究遗传多样性程度和了解不同群体间的群体结构。本研究的目的是找出印度恰蒂斯加尔邦的三个部落人口,即哈尔巴、加德巴和奥拉恩之间的亲和力和多样性程度。它们属于不同的语系。哈尔巴语属于印欧语系,加德巴语属于南亚语系,而奥拉恩语属于德拉威语系。对160例无亲缘关系男女的7个广泛分布的多态性插入/缺失位点(Alu APO、Alu ACE、Alu D1、Alu PV92、Alu FXIIIB、Alu CD4 del和Alu PLAT)进行了分析。除Alu CD4 del位点外,其余位点高度多态性。3个部落CD4位点杂合性最低。Alu PLAT位点的GST值最低(0.0004),而Alu PV92位点的GST值最高(0.1029)。无根邻居连接树(NJ)显示Gadba和Oraon部落为一个集群,而Halba部落与他们有区别。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Study of Genomic Diversity of Three Tribal Populations of Chhattisgarh, India
The diverse linguistic and ethnic tribal populations harboring state Chhattisgarh is a hotspot for human genomic diversity research. Genetic analysis of individual variation at the DNA level is widely used to investigate the extent of genetic diversity and to understand the population structure among different populations. The present study was conducted to find out the extent of affinities and diversities among three tribal populations of Chhattisgaarh, India namely Halba, Gadba and Oraon. They belong to different language families. Halba belongs to Indo-European, Gadba belongs to Austro-Asiatic while Oraon belongs to Dravidian language family. Analysis on seven widely distributed polymorphic insertion/deletion loci (Alu APO, Alu ACE, Alu D1, Alu PV92, Alu FXIIIB, Alu CD4 del and Alu PLAT) in 160 unrelated individuals of both sexes were done. All loci were highly polymorphic except Alu CD4 del locus. All the three tribes showed lowest heterozygosity for CD4 locus. GST value was recorded lowest for Alu PLAT locus (0.0004) while the highest was recorded for Alu PV92 locus (0.1029). The unrooted Neighbor-Joining (NJ) tree showed Gadba and Oraon form one cluster while Halba tribe differentiates from them.
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