重组人α干扰素(INF)对慢性粒细胞白血病(CGL)骨髓造血祖细胞克隆生长的影响

Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01

A Zduńczyk, H Miszta, Z Dabrowski

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引用次数: 0

摘要

通过体外培养慢性粒细胞白血病(CGL)患者骨髓，研究了重组α干扰素(INF)对集落刺激因子(CSF)产生的影响。我们可以发现，将干扰素添加到预孵育的外周血植物血凝素(PHA)淋巴细胞悬浮液中，可以抑制人类自体骨髓培养中集落和簇的形成。

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Effect of recombinant human alpha interferon (INF) on chronic granulocytic leukaemia (CGL) clonogenic growth of bone marrow haematopoietic progenitors.

The effect of recombinant alpha interferon (INF) to the colony stimulating factor (CSF) production was examined with in vitro culture of the bone marrow of patients with chronic granulocytic leukaemia (CGL). It could be found that addition of interferon into a suspension of preincubated phytohaemagglutinin (PHA) lymphocytes from peripheral blood represents an inhibity factor for colony and cluster formation in autologic human marrow cultures.

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Folia haematologica (Leipzig, Germany : 1928)

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