[维生素A——生长、分化和形态发生研究中的探针]。

S Koussoulakos, H J Anton
{"title":"[维生素A——生长、分化和形态发生研究中的探针]。","authors":"S Koussoulakos,&nbsp;H J Anton","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Scientific work on vitamin A research has started more than one hundred years ago. The information accumulated thus far has already been published in thousands of original papers, review articles, monographic series and books. The overall result of these investigations can be concentrated in the title of the present review. Vitamin A and its analogues, the retinoids, participate directly in several physiological functions, such as vision, growth, development and differentiation. These compounds have also found useful application in the cure of several serious dermatological diseases and in cancer therapy. Their activities are also widely exploited to study embryogenesis, teratogenesis and carcinogenesis. Recent advances ascribe to retinoic acid properties, which render it a putative candidate for the first vertebrate morphogen. These developments, in combination with progress made in the study of homeo box genes, open new ways towards elucidating the mode of action of retinoids at the molecular level. It is tempting to speculate that, understanding enough about the basic biology of retinoid action, might be beneficially exploited for the betterment of the mankind.</p>","PeriodicalId":14529,"journal":{"name":"Izvestiia Akademii nauk SSSR. Seriia biologicheskaia","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Vitamin A--a probe in the study of growth, differentiation and morphogenesis].\",\"authors\":\"S Koussoulakos,&nbsp;H J Anton\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Scientific work on vitamin A research has started more than one hundred years ago. The information accumulated thus far has already been published in thousands of original papers, review articles, monographic series and books. The overall result of these investigations can be concentrated in the title of the present review. Vitamin A and its analogues, the retinoids, participate directly in several physiological functions, such as vision, growth, development and differentiation. These compounds have also found useful application in the cure of several serious dermatological diseases and in cancer therapy. Their activities are also widely exploited to study embryogenesis, teratogenesis and carcinogenesis. Recent advances ascribe to retinoic acid properties, which render it a putative candidate for the first vertebrate morphogen. These developments, in combination with progress made in the study of homeo box genes, open new ways towards elucidating the mode of action of retinoids at the molecular level. It is tempting to speculate that, understanding enough about the basic biology of retinoid action, might be beneficially exploited for the betterment of the mankind.</p>\",\"PeriodicalId\":14529,\"journal\":{\"name\":\"Izvestiia Akademii nauk SSSR. Seriia biologicheskaia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Izvestiia Akademii nauk SSSR. Seriia biologicheskaia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Izvestiia Akademii nauk SSSR. Seriia biologicheskaia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

关于维生素A的科学研究工作早在一百多年前就开始了。迄今为止积累的信息已经发表在数千篇原创论文、评论文章、专题丛书和书籍中。这些调查的总体结果可以集中在本综述的标题中。维生素A及其类似物类维生素A直接参与多种生理功能,如视力、生长、发育和分化。这些化合物在治疗几种严重皮肤病和癌症治疗中也有很好的应用。它们的活性也被广泛用于胚胎发生、致畸和致癌的研究。最近的进展归因于维甲酸的性质,这使其成为假定的第一个脊椎动物形态原的候选者。这些进展与同源盒基因的研究进展相结合,为在分子水平上阐明类维生素a的作用模式开辟了新的途径。这很容易让人推测,对类维生素a作用的基本生物学有足够的了解,可能会有益于人类的改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Vitamin A--a probe in the study of growth, differentiation and morphogenesis].

Scientific work on vitamin A research has started more than one hundred years ago. The information accumulated thus far has already been published in thousands of original papers, review articles, monographic series and books. The overall result of these investigations can be concentrated in the title of the present review. Vitamin A and its analogues, the retinoids, participate directly in several physiological functions, such as vision, growth, development and differentiation. These compounds have also found useful application in the cure of several serious dermatological diseases and in cancer therapy. Their activities are also widely exploited to study embryogenesis, teratogenesis and carcinogenesis. Recent advances ascribe to retinoic acid properties, which render it a putative candidate for the first vertebrate morphogen. These developments, in combination with progress made in the study of homeo box genes, open new ways towards elucidating the mode of action of retinoids at the molecular level. It is tempting to speculate that, understanding enough about the basic biology of retinoid action, might be beneficially exploited for the betterment of the mankind.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信