{"title":"庆大霉素致大鼠肾毒性的实验研究","authors":"R. Saha, Sar Choudhury","doi":"10.3329/BJA.V7I2.6088","DOIUrl":null,"url":null,"abstract":"Context: Gentamicin is an antibiotic used in gram-negative infection. It is an nephrotoxic agent. Proximal tubular epithelial cells are selectively sensitive to gentamicin. Objective: To observe the toxic effect of gentamicin on epithelial cells of proximal convoluted tubule in Long Evans rats. Study design: An experimental study. Plan and period of study: The study was carried out in the Department of Pharmacology of IPGMR Dhaka during the period of 1995 to 1996. Materials and methods: Eighteen mature long Evans rats were divided into three groups A, B & C. The rats of group A were treated with vehicle and group B and C were treated with gentamicin 50gm and 100gm respectively. Blood urea and serum creatinine were measured and microscopic damaged cells were counted. Result: There was significant increase in serum creatinin and blood urea in gentamicin treated groups. Microscopic examination of kidney showed necrosis of proximal tubular cells. Conclusion: It can be concluded from this study that gentamicin has toxic effects on renal tubule. Key words: Gentamicin. DOI: 10.3329/bja.v7i2.6088 Bangladesh J. Anat. 2009; 7(2) :84-86","PeriodicalId":284932,"journal":{"name":"Bangladesh Journal of Anatomy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2010-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Gentamicin Induced Nephrotoxicity in Long Evans Rat - An Experimental Study\",\"authors\":\"R. Saha, Sar Choudhury\",\"doi\":\"10.3329/BJA.V7I2.6088\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Context: Gentamicin is an antibiotic used in gram-negative infection. It is an nephrotoxic agent. Proximal tubular epithelial cells are selectively sensitive to gentamicin. Objective: To observe the toxic effect of gentamicin on epithelial cells of proximal convoluted tubule in Long Evans rats. Study design: An experimental study. Plan and period of study: The study was carried out in the Department of Pharmacology of IPGMR Dhaka during the period of 1995 to 1996. Materials and methods: Eighteen mature long Evans rats were divided into three groups A, B & C. The rats of group A were treated with vehicle and group B and C were treated with gentamicin 50gm and 100gm respectively. Blood urea and serum creatinine were measured and microscopic damaged cells were counted. Result: There was significant increase in serum creatinin and blood urea in gentamicin treated groups. Microscopic examination of kidney showed necrosis of proximal tubular cells. Conclusion: It can be concluded from this study that gentamicin has toxic effects on renal tubule. Key words: Gentamicin. DOI: 10.3329/bja.v7i2.6088 Bangladesh J. Anat. 2009; 7(2) :84-86\",\"PeriodicalId\":284932,\"journal\":{\"name\":\"Bangladesh Journal of Anatomy\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bangladesh Journal of Anatomy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3329/BJA.V7I2.6088\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bangladesh Journal of Anatomy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/BJA.V7I2.6088","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Gentamicin Induced Nephrotoxicity in Long Evans Rat - An Experimental Study
Context: Gentamicin is an antibiotic used in gram-negative infection. It is an nephrotoxic agent. Proximal tubular epithelial cells are selectively sensitive to gentamicin. Objective: To observe the toxic effect of gentamicin on epithelial cells of proximal convoluted tubule in Long Evans rats. Study design: An experimental study. Plan and period of study: The study was carried out in the Department of Pharmacology of IPGMR Dhaka during the period of 1995 to 1996. Materials and methods: Eighteen mature long Evans rats were divided into three groups A, B & C. The rats of group A were treated with vehicle and group B and C were treated with gentamicin 50gm and 100gm respectively. Blood urea and serum creatinine were measured and microscopic damaged cells were counted. Result: There was significant increase in serum creatinin and blood urea in gentamicin treated groups. Microscopic examination of kidney showed necrosis of proximal tubular cells. Conclusion: It can be concluded from this study that gentamicin has toxic effects on renal tubule. Key words: Gentamicin. DOI: 10.3329/bja.v7i2.6088 Bangladesh J. Anat. 2009; 7(2) :84-86
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