免疫疗法IHC标记在阴茎癌(HPV男性疫苗)中表达的相关性和局限性。进化的结果

Ghirardi Graciela Rosa, Carmelo Caballero
{"title":"免疫疗法IHC标记在阴茎癌(HPV男性疫苗)中表达的相关性和局限性。进化的结果","authors":"Ghirardi Graciela Rosa, Carmelo Caballero","doi":"10.47363/jpr/2022(4)149","DOIUrl":null,"url":null,"abstract":"Introduction: Penile cancer is not common in developed countries, although it is common in some Latin American countries. It is related to cervical cancer, it has two independent cancer pathways, according to its link or not, with HPV. Therefore, it is relevant to promote vaccination in young men. Given the clinical / oncological management has new treatment proposals based on immunotherapy (IT), which favors preservation of the organ, the pathology reports must be increasingly strict in terms of classification, Immunohistochemical (IHC) markers, and therapeutic strategies. Objectives: To assess the perspective on the use of established HPV and IT IHC markers to establish the relevance of their use; determine the specificity and sensitivity of the markers through IHC. Materials and methods: 27 samples of penile cancer were evaluated, from patients from Paraguay, who underwent HPV IHC and IT to establish their relevance with 16 markers. Results: The IHQ markers: MCM2, MDM2 and HSP-27 were very significant in the cancer / HPV ratio; PDL-1, CD4, CD8 and B7H3 were relevant for IT. According to our results, we recommend the HSP-27 and the B7H3 as markers. Conclusion: The management of samples and histopathological typing should be performed by experienced pathologists in the pathogenesis, classification and therapeutic of penile cancer. It remains to unveil its real practical use, the degree of participation of agents and or cofactors, the local and systemic immune response, new drugs and vaccine efficacy. We suggest expanding the number of cases to confirm these results.","PeriodicalId":253047,"journal":{"name":"Journal of Pathology Research Reviews & Reports","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relevance and Limitations in the Expression of Immunotherapy IHC Markers in Penile Cancer (HPV Male Vaccine). An Outcome in Evolution\",\"authors\":\"Ghirardi Graciela Rosa, Carmelo Caballero\",\"doi\":\"10.47363/jpr/2022(4)149\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Penile cancer is not common in developed countries, although it is common in some Latin American countries. It is related to cervical cancer, it has two independent cancer pathways, according to its link or not, with HPV. Therefore, it is relevant to promote vaccination in young men. Given the clinical / oncological management has new treatment proposals based on immunotherapy (IT), which favors preservation of the organ, the pathology reports must be increasingly strict in terms of classification, Immunohistochemical (IHC) markers, and therapeutic strategies. Objectives: To assess the perspective on the use of established HPV and IT IHC markers to establish the relevance of their use; determine the specificity and sensitivity of the markers through IHC. Materials and methods: 27 samples of penile cancer were evaluated, from patients from Paraguay, who underwent HPV IHC and IT to establish their relevance with 16 markers. Results: The IHQ markers: MCM2, MDM2 and HSP-27 were very significant in the cancer / HPV ratio; PDL-1, CD4, CD8 and B7H3 were relevant for IT. According to our results, we recommend the HSP-27 and the B7H3 as markers. Conclusion: The management of samples and histopathological typing should be performed by experienced pathologists in the pathogenesis, classification and therapeutic of penile cancer. It remains to unveil its real practical use, the degree of participation of agents and or cofactors, the local and systemic immune response, new drugs and vaccine efficacy. We suggest expanding the number of cases to confirm these results.\",\"PeriodicalId\":253047,\"journal\":{\"name\":\"Journal of Pathology Research Reviews & Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pathology Research Reviews & Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47363/jpr/2022(4)149\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pathology Research Reviews & Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47363/jpr/2022(4)149","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

导读:阴茎癌在发达国家并不常见,但在一些拉丁美洲国家很常见。它与宫颈癌有关,它有两个独立的癌症途径,根据它是否与HPV有关。因此,在年轻男性中推广疫苗接种具有重要意义。鉴于临床/肿瘤管理有基于免疫治疗(IT)的新治疗建议,这有利于器官的保存,病理报告必须在分类,免疫组织化学(IHC)标记物和治疗策略方面越来越严格。目的:评估已建立的HPV和IT IHC标志物的使用前景,以确定其使用的相关性;通过免疫组化法确定标记物的特异性和敏感性。材料和方法:对来自巴拉圭的27例阴茎癌患者进行HPV IHC和IT检查,以确定其与16种标志物的相关性。结果:IHQ标志物MCM2、MDM2和HSP-27对癌/ HPV比值有显著影响;PDL-1、CD4、CD8、B7H3与IT相关。根据我们的结果,我们推荐HSP-27和B7H3作为标记物。结论:阴茎癌的发病机制、分型和治疗应由经验丰富的病理医师进行标本处理和组织病理分型。它仍有待揭示其真正的实际用途、制剂和/或辅助因子的参与程度、局部和全身免疫反应、新药和疫苗功效。我们建议扩大病例数,以证实这些结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relevance and Limitations in the Expression of Immunotherapy IHC Markers in Penile Cancer (HPV Male Vaccine). An Outcome in Evolution
Introduction: Penile cancer is not common in developed countries, although it is common in some Latin American countries. It is related to cervical cancer, it has two independent cancer pathways, according to its link or not, with HPV. Therefore, it is relevant to promote vaccination in young men. Given the clinical / oncological management has new treatment proposals based on immunotherapy (IT), which favors preservation of the organ, the pathology reports must be increasingly strict in terms of classification, Immunohistochemical (IHC) markers, and therapeutic strategies. Objectives: To assess the perspective on the use of established HPV and IT IHC markers to establish the relevance of their use; determine the specificity and sensitivity of the markers through IHC. Materials and methods: 27 samples of penile cancer were evaluated, from patients from Paraguay, who underwent HPV IHC and IT to establish their relevance with 16 markers. Results: The IHQ markers: MCM2, MDM2 and HSP-27 were very significant in the cancer / HPV ratio; PDL-1, CD4, CD8 and B7H3 were relevant for IT. According to our results, we recommend the HSP-27 and the B7H3 as markers. Conclusion: The management of samples and histopathological typing should be performed by experienced pathologists in the pathogenesis, classification and therapeutic of penile cancer. It remains to unveil its real practical use, the degree of participation of agents and or cofactors, the local and systemic immune response, new drugs and vaccine efficacy. We suggest expanding the number of cases to confirm these results.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信