M. Ali, M. Jesmin, Mohammud K. Islam, F. Khatun, A. Azad
{"title":"丙酮硫脲对小鼠埃利希腹水癌细胞的抗肿瘤活性","authors":"M. Ali, M. Jesmin, Mohammud K. Islam, F. Khatun, A. Azad","doi":"10.12816/0001498","DOIUrl":null,"url":null,"abstract":"SUMMARY: A schiff base acetone semicarbazone has been synthesized and characterized. Its anticancer activities have been studied against Ehrlich Ascites Carcinoma (EAC) cells in swiss albino mice by monitoring the parameters like tumour cell growth inhibition, tumour weight, survival time, peritoneal cells and haematological parameters. It was found that this compound significantly reduces tumour cell growth rate, decreases tumour weight and increases life span in comparison to those of EAC bearing mice. The test compound restored the depleted haematological parameters of EAC bearing mice towards normal. The compound also enhanced number of macrophages in normal mice. The results obtained were compared with those obtained with the standard drug bleomycin.","PeriodicalId":351803,"journal":{"name":"medical journal of islamic world academy of sciences","volume":"28 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"ANTINEOPLASTIC ACTIVITIES OF ACETONE THIOSEMICARBAZONE AGAINST EHRLICH ASCITES CARCINOMA CELLS BEARING MICE\",\"authors\":\"M. Ali, M. Jesmin, Mohammud K. Islam, F. Khatun, A. Azad\",\"doi\":\"10.12816/0001498\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"SUMMARY: A schiff base acetone semicarbazone has been synthesized and characterized. Its anticancer activities have been studied against Ehrlich Ascites Carcinoma (EAC) cells in swiss albino mice by monitoring the parameters like tumour cell growth inhibition, tumour weight, survival time, peritoneal cells and haematological parameters. It was found that this compound significantly reduces tumour cell growth rate, decreases tumour weight and increases life span in comparison to those of EAC bearing mice. The test compound restored the depleted haematological parameters of EAC bearing mice towards normal. The compound also enhanced number of macrophages in normal mice. The results obtained were compared with those obtained with the standard drug bleomycin.\",\"PeriodicalId\":351803,\"journal\":{\"name\":\"medical journal of islamic world academy of sciences\",\"volume\":\"28 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medical journal of islamic world academy of sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.12816/0001498\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medical journal of islamic world academy of sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12816/0001498","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
ANTINEOPLASTIC ACTIVITIES OF ACETONE THIOSEMICARBAZONE AGAINST EHRLICH ASCITES CARCINOMA CELLS BEARING MICE
SUMMARY: A schiff base acetone semicarbazone has been synthesized and characterized. Its anticancer activities have been studied against Ehrlich Ascites Carcinoma (EAC) cells in swiss albino mice by monitoring the parameters like tumour cell growth inhibition, tumour weight, survival time, peritoneal cells and haematological parameters. It was found that this compound significantly reduces tumour cell growth rate, decreases tumour weight and increases life span in comparison to those of EAC bearing mice. The test compound restored the depleted haematological parameters of EAC bearing mice towards normal. The compound also enhanced number of macrophages in normal mice. The results obtained were compared with those obtained with the standard drug bleomycin.