{"title":"夹尾刺激使麻醉大鼠海马锁相神经元增多","authors":"Y. Wang, X. J. Zheng, Z. Feng","doi":"10.1109/BHI.2014.6864472","DOIUrl":null,"url":null,"abstract":"Phase-locking is an important encoding mode in the hippocampal region of brain where neuronal firing concentrates on a certain phase of the periodic field potential, especially θ rhythm. It can be observed during many behaviors while the locked-phase varies accordingly. In this study, the changes of neuronal phase-locking induced by somatosensory stimulation of tail-clamping were investigated. The local field potential and spike signals were recorded in hippocampal CA1 region of anesthetized rats with microelectrode array. The phase-locking relationship was analyzed with Raleigh test and spike-phase histogram. The results showed that during spontaneous activity, 3 of 20 examined neurons were phase-locking to the θ rhythm of the field potential. However, during the tail clamping periods, the number of phase-locking neurons increased from 3 to 8, and the mean locked-phase shifted towards the negative peak of the field potential cycle, which became θ rhythm dominated. These findings suggest that the hippocampus may encode somatosensory information with the phase-locking neurons and by shifting their locked-phases.","PeriodicalId":177948,"journal":{"name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","volume":"193 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tail-clamping stimulation increases phase-locking neurons in the hippocampus of anaesthetized rat\",\"authors\":\"Y. Wang, X. J. Zheng, Z. Feng\",\"doi\":\"10.1109/BHI.2014.6864472\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Phase-locking is an important encoding mode in the hippocampal region of brain where neuronal firing concentrates on a certain phase of the periodic field potential, especially θ rhythm. It can be observed during many behaviors while the locked-phase varies accordingly. In this study, the changes of neuronal phase-locking induced by somatosensory stimulation of tail-clamping were investigated. The local field potential and spike signals were recorded in hippocampal CA1 region of anesthetized rats with microelectrode array. The phase-locking relationship was analyzed with Raleigh test and spike-phase histogram. The results showed that during spontaneous activity, 3 of 20 examined neurons were phase-locking to the θ rhythm of the field potential. However, during the tail clamping periods, the number of phase-locking neurons increased from 3 to 8, and the mean locked-phase shifted towards the negative peak of the field potential cycle, which became θ rhythm dominated. These findings suggest that the hippocampus may encode somatosensory information with the phase-locking neurons and by shifting their locked-phases.\",\"PeriodicalId\":177948,\"journal\":{\"name\":\"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)\",\"volume\":\"193 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/BHI.2014.6864472\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/BHI.2014.6864472","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Tail-clamping stimulation increases phase-locking neurons in the hippocampus of anaesthetized rat
Phase-locking is an important encoding mode in the hippocampal region of brain where neuronal firing concentrates on a certain phase of the periodic field potential, especially θ rhythm. It can be observed during many behaviors while the locked-phase varies accordingly. In this study, the changes of neuronal phase-locking induced by somatosensory stimulation of tail-clamping were investigated. The local field potential and spike signals were recorded in hippocampal CA1 region of anesthetized rats with microelectrode array. The phase-locking relationship was analyzed with Raleigh test and spike-phase histogram. The results showed that during spontaneous activity, 3 of 20 examined neurons were phase-locking to the θ rhythm of the field potential. However, during the tail clamping periods, the number of phase-locking neurons increased from 3 to 8, and the mean locked-phase shifted towards the negative peak of the field potential cycle, which became θ rhythm dominated. These findings suggest that the hippocampus may encode somatosensory information with the phase-locking neurons and by shifting their locked-phases.