Research Progress on the Synthesis of Flavonoids by Saccharomyces Cerevisiae

As a food-safe microorganism, Saccharomyces cerevisiae is widely studied in metabolic engineering and synthetic biology, and can be used as a cell factory to produce natural compounds. Flavonoids are valuable natural products with multiple biological activities such as estrogen, antioxidant, antibacterial and anticancer activities, and are widely used in food, medicine and other fields. However, the development and utilization of flavonoids is limited by problems such as low concentration and long cycle in obtaining them from plants. With the development of metabolic engineering technology and synthetic biology, the synthesis of flavonoids through microbial cell factories has good prospects. Based on microbial synthesis of flavonoids, this paper comprehensively reviews the research progress of some flavonoids synthesized in S. cerevisiae, summarizes and prospects the current difficulties and challenges as well as future research directions.