基于布尔网络和人工神经网络的基因表达建模

T. Kubik, K. Bogunia-Kubik, M. Sugisaka
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引用次数: 0

摘要

分子生物学的最新进展使人们能够探索生物体内遗传信息处理的机制。随着新技术的使用,可以观察细胞在不同时间步长的状态,组装和拆卸遗传信息载体等。随着新工具的出现,我们有机会回答激励我们前辈的问题。有机会发现“这一切是如何运作的?”本文研究了一种基因网络建模方法。基因网络是由大量基因通过表达相互作用而形成的。该模型用于在基因表达测量的基础上推断基因表达机制。在我们的方法中,我们采用了两种网络模型:布尔网络模型和人工神经网络模型。我们已经证明,在已经开发的方法和算法的帮助下,可以有效地处理大数据。多亏了它们,从大量基因表达数据中得出有意义的推论可能会变成简单的任务。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gene expression modelling with the use of Boolean network and artificial neural network
Recent progress in molecular biology has enabled exploration of the mechanisms of genetic information processing in organisms. With the use of new technologies it is possible to observe a state of the cell at different time steps, assemble and disassemble genetic information carriers, etc. With new tools available there is a chance to answer the question that has motivated our predecessors. There is a chance to find out "how it all works?" In this paper we study a method of gene networks modelling. A gene network is a mass of genes interacting with one another through expression. The model is used to infer a gene expression mechanism on the basis of gene expression measurements. In our approach we employed two network models: a Boolean network model and an artificial neural network model. We have shown that large data can be handled efficiently with the aid of already developed methods and algorithms. Thanks to them, drawing meaningful inferences from large gene expression data may be converted into simple tasks.
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