菠萝蛋白酶与胰蛋白酶-凝乳胰蛋白酶在处理下颌第三磨牙手术切除后并发症中的作用

M. Nanjappa, Shivani, Somak Saha
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引用次数: 0

摘要

手术切除第三磨牙仍然是口腔颌面外科医生最常见的常规手术,通常伴有术后后遗症。为了避免或减少术后并发症,如肿胀、疼痛和牙关紧闭,建议患者在常规抗生素的同时使用蛋白水解酶和非甾体抗炎药。研究对象为50例双侧对称阻生下颌第三磨牙患者。术后给予抗生素和镇痛药5 d。患者在手术后给予一侧菠萝蛋白酶5天,另一侧给予胰蛋白酶-凝乳胰蛋白酶5天,两次手术之间间隔21天。患者于第1天、第3天和第7天被召回,根据测量切间距离、视觉模拟量表和面部参考点评估术后牙关、疼痛和肿胀。采用SPSS软件收集资料,采用描述性统计和卡方检验进行统计评价。本研究得出的结论是菠萝蛋白酶对阻生第三磨牙手术后的肿胀、开口和疼痛的影响明显大于胰凝乳蛋白酶。我们建议使用它来减少第三磨牙手术切除后的肿胀和疼痛。然而,需要更大样本量和随机化的进一步研究来证实这一点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bromelain vs trypsin-chymotrypsin in management of complications following surgical removal of mandibular third molar
Surgical removal of third molars is still the most common routine surgical procedure done by oral and maxillofacial surgeons which is usually associated with postoperative sequelae. In order to avoid or minimize post-surgical complications such as swelling, pain and trismus, patients are advised to use proteolytic enzyme and NSAID’s along with routine antibiotics. 50 patients who have bilateral symmetrical impacted mandibular third molars were included in the study. Post operatively, all patients were given antibiotics and analgesics for 5 days. Patients were given bromelain for 5 days after the procedure on one side and trypsin-chymotrypsin for 5 days on the other side with an interval of 21 days between the two procedures. Patients were recalled on day 1, day 3 and day 7 for assessment of post- operative trismus, pain and swelling based on measuring inter-incisal distance, visual analogue scale and, facial reference points. Data was gathered and statistical assessment was done using SPSS software by using descriptive statistics and chi square test. The conclusion drawn from the study was that bromelain has a significant effect on swelling, mouth opening and pain after surgical removal of impacted third molar than chymotrypsin. We suggest its usage in reduction of swelling and pain post operatively after surgical removal of third molar. However further studies with larger sample size and randomizations are required to confirm the same.
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