微纳粒子操作与应用的多功能光电平台

2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS) Pub Date : 2017-07-26 DOI:10.1109/TRANSDUCERS.2017.7994088

H. Chuang, H. -. Lin, D. Shieh

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引用次数: 0

摘要

本文提出了一种简单的光电动力学方法，通过同时诱导电流体流动和电运动来操纵粒子。通过仔细调整作用在粒子上的几种力之间的平衡，实现了包括聚合、平移、排序和图案在内的多种操作能力。结合基于头部的免疫测定，我们成功地对稀释分析物(~ 10 pg/mL)，肿瘤坏死因子-α (TNF-α)进行了荧光信号增强，并实现了同时检测双重生物标志物的概念验证。这种技术的发展可以为早期诊断疾病提供见解。

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A multi-functionally optoelectric platform for micro/nano particle manipulation and applications

This paper presents a simple optoelectrokinetic method for manipulating particles by simultaneously inducing electrohydrodnamic flow and electrokinetic motion. With carefully tuning the balance between several forces acting on particles, multiple manipulation capabilities including aggregation, translation, sorting, and patterning were achieved. In combination with bead-based immunoassays, we successfully performed fluorescent signal enhancement for a dilute analyte (∼10 pg/mL), tumor necrosis factor-alpha (TNF-α), and achieved a proof of concept for simultaneous detection of dual biomarkers. The development of such a technique can provide insight to diagnosing diseases in the early stage.

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2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)

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