低温保护剂及其在低温保存中的应用

Sankha Bhattacharya
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引用次数: 49

摘要

冷冻保护剂基本上是一些防止细胞或组织因冷冻而受损的化合物。冷冻保存多采用玻璃化和解冻工艺。如今,随着近年来许多器官和组织移植方法的发展,冷冻保存正在成为卫生部门的尖端技术。器官或组织在植入前需要妥善保存,因此冷冻保护剂在现代人体冷冻技术中起着关键作用。本文旨在为冷冻保护剂如何工作和防止在冷冻干燥或玻璃化过程中因冰晶萎缩而造成组织损伤提供答案。各种动物组织、器官、淋巴细胞、软骨、骨髓、蛋白质可以通过使用适当的冷冻保护剂来保存。低温保护剂的优化是一项具有挑战性的任务,因为浓度升高可能导致细胞毒性。本文还重点介绍了冷冻保护剂及其类型的含义、挑战和最新进展。本文还强调了冷冻银行系统的重要性及其重要性。此外,本文还讨论了低温保护剂在纳米悬浮液制备中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cryopretectants and Their Usage in Cryopreservation Process
Cryoprotectants are basically some chemical compounds which prevent cells or tissues from damage due to freezing. Mostly vitrification and thawing process are mostly used in cryopreservation. Now a day’s cryopreservation is becoming an apex technology for Health sector, as many organ and tissue transplant methods has been developed in recent time. Organs or tissues need to preserve properly before implantation, hence cryoprotectants plays a key role modern cryonics. This article seeks to provide answers for how cryoprotectants works and prevent tissue damage from shrinking ice crystals during freeze drying or vitrification. The various animal tissues, organs, lymphocytes, cartilages, bone marrow, proteins can be stored by using proper cryoprotectants. Optimization of cryoprotectants is a challenging task, as elevated concentration may cause cytotoxicity. This article also highlights the implication, challenges and recent advances of cryoprotectants along with its types. The importance of cryobank system and its importance were also being emphasized in this article. Further, importance of cryoprotectants in nano suspension preparation was also been discussed in this article.
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