哌替啶:当代用法透视

M. Gitlin
{"title":"哌替啶:当代用法透视","authors":"M. Gitlin","doi":"10.1300/J088V09N03_01","DOIUrl":null,"url":null,"abstract":"Meperidine, a phenylpiperidine derivative, was the first synthetic opioid. Introduced in 1939, it has remained a widely used agent. It has been estimated to constitute approximately 40% of total analgesic utilization in Western countries.1 Despite this widespread utilization, there is considerable debate on the wisdom of the continued use of this drug. Chalverus2 in this issue of the Journal of Pharmaceutical Care in Pain & Symptom Control has made a contribution to this debate by reviewing the toxicity of this opioid. The pharmacokinetics of meperidine certainly make it far from an ideal opioid. There is extensive first-pass hepatic metabolism; the oral bioavailability has been reported to range from 40 to 60%.3 Administered intravenously, single dose meperidine provides a short duration of analgesia. Extensive redistribution initially to well perfused regions occurs and repetitive dosing results in uptake by adipose tissue. Despite the acknowledged relatively short duration of action of meperidine of one to three hours, it is not uncommonly administered at intervals of ev-","PeriodicalId":268184,"journal":{"name":"Journal of Pharmaceutical Care in Pain & Symptom Control","volume":"35 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Meperidine: A Perspective on Its Contemporary Use\",\"authors\":\"M. Gitlin\",\"doi\":\"10.1300/J088V09N03_01\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Meperidine, a phenylpiperidine derivative, was the first synthetic opioid. Introduced in 1939, it has remained a widely used agent. It has been estimated to constitute approximately 40% of total analgesic utilization in Western countries.1 Despite this widespread utilization, there is considerable debate on the wisdom of the continued use of this drug. Chalverus2 in this issue of the Journal of Pharmaceutical Care in Pain & Symptom Control has made a contribution to this debate by reviewing the toxicity of this opioid. The pharmacokinetics of meperidine certainly make it far from an ideal opioid. There is extensive first-pass hepatic metabolism; the oral bioavailability has been reported to range from 40 to 60%.3 Administered intravenously, single dose meperidine provides a short duration of analgesia. Extensive redistribution initially to well perfused regions occurs and repetitive dosing results in uptake by adipose tissue. Despite the acknowledged relatively short duration of action of meperidine of one to three hours, it is not uncommonly administered at intervals of ev-\",\"PeriodicalId\":268184,\"journal\":{\"name\":\"Journal of Pharmaceutical Care in Pain & Symptom Control\",\"volume\":\"35 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmaceutical Care in Pain & Symptom Control\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1300/J088V09N03_01\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Care in Pain & Symptom Control","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1300/J088V09N03_01","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

甲哌啶是苯基哌啶衍生物,是第一个合成的阿片类药物。自1939年推出以来,它一直是一种广泛使用的药物。据估计,它约占西方国家总镇痛药使用的40%尽管这种药物被广泛使用,但对于继续使用这种药物是否明智,仍存在相当大的争论。Chalverus2在本期的《疼痛与症状控制的药学护理》杂志上通过回顾这种阿片类药物的毒性,为这场辩论做出了贡献。哌替啶的药代动力学使它远非理想的阿片类药物。有广泛的首过肝脏代谢;据报道,口服生物利用度为40%至60%静脉给药,单剂量哌替啶提供短时间的镇痛。最初会发生广泛的再分布到灌注良好的区域,重复给药会导致脂肪组织吸收。尽管公认哌替啶的作用时间相对较短,为1至3小时,但它通常以ev-的间隔给药
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Meperidine: A Perspective on Its Contemporary Use
Meperidine, a phenylpiperidine derivative, was the first synthetic opioid. Introduced in 1939, it has remained a widely used agent. It has been estimated to constitute approximately 40% of total analgesic utilization in Western countries.1 Despite this widespread utilization, there is considerable debate on the wisdom of the continued use of this drug. Chalverus2 in this issue of the Journal of Pharmaceutical Care in Pain & Symptom Control has made a contribution to this debate by reviewing the toxicity of this opioid. The pharmacokinetics of meperidine certainly make it far from an ideal opioid. There is extensive first-pass hepatic metabolism; the oral bioavailability has been reported to range from 40 to 60%.3 Administered intravenously, single dose meperidine provides a short duration of analgesia. Extensive redistribution initially to well perfused regions occurs and repetitive dosing results in uptake by adipose tissue. Despite the acknowledged relatively short duration of action of meperidine of one to three hours, it is not uncommonly administered at intervals of ev-
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信