雅库特人群慢性乙型肝炎患者nos3和cyba多态性与肝硬化频率的关系

Soloveva Yu.A., Borisova N.V., Malogulova I.Sh.
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摘要

慢性乙型病毒性肝炎是一个重大的公共卫生问题。肝炎病毒携带者因素影响慢性乙型肝炎的病程和进展为肝硬化的几率。因此,研究慢性乙型肝炎并发症的早期发育遗传预测因子具有重要意义。NOS3和CYBA基因可以作为肝脏早期纤维化过程的预测基因。研究证实了氧化应激和细胞衰老在肝纤维化发生中的作用。本研究的目的是确定在雅库特人群中携带NOS3和CYBA基因多态性与慢性乙型病毒性肝炎患者肝纤维化的关系。对417人进行了NOS3基因rs1799983、rs1801131、CYBA基因rs4673 snp的分子遗传学研究。代表性材料的收集是在雅库特共和国临床医院传染病科和东北医科大学诊所的基础上进行的。通过遗传学研究发现,携带NOS3基因rs1799983多态性突变等位基因的人发生肝硬化的概率比携带CYBA基因rs4673突变等位基因的人高1.81倍(0.176 ~ 0.098,CI 95%),携带CYBA基因rs4673突变等位基因的人发生肝硬化的概率比携带NOS3基因rs2070744多态性突变等位基因的人高1.9倍(0.211 ~ 0.111,CI 95%),携带NOS3基因rs2070744多态性突变等位基因的人发生肝硬化的概率比携带NOS3基因rs1799983多态性突变等位基因的人高1.9倍(0.211 ~ 0.111,CI 95%)。发生肝硬化的概率高出2.03倍(0.181 ~ 0.089,CI 95%)。因此,获得的结果表明需要对这些基因进行更多的研究,因为它们可以预测雅库特人群中慢性乙型肝炎患者肝硬化的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ASSOCIATION OF NOS3 AND CYBA POLYMORPHISMS WITH FREQUENCY OF LIVER CIRRHOSIS IN PATIENTS WITH CHRONIC HEPATITIS B IN THE YAKUT POPULATION
Chronic viral hepatitis B is a significant public health problem. Hepatitis virus carrier factors affect the course of chronic hepatitis B and odds of progression to liver cirrhosis. So, the research for the early development genetic predictors of complications of chronic hepatitis B is relevant. NOS3 and CYBA genes can act as predictor genes for early fibrotic processes in the liver. Researches confirm the role of oxidative stress and the mechanisms of cellular aging in the development of liver fibrosis. The purpose of this study is to identify the relationship between the carriage of polymorphisms of the NOS3 and CYBA genes and the development of liver fibrosis in patients with chronic viral hepatitis B in the Yakut population. Molecular genetic study of SNPs rs1799983 and rs1801131 of the NOS3 gene, rs4673 of the CYBA gene was carried out on 417 people. The collection of representative material was carried out on the basis of the Infectious Diseases Department of the Yakut Republican Clinical Hospital and the NEFU Clinic. As a result of a genetic study, it was found that in carriers of the mutant allele for the rs1799983 polymorphism of the NOS3 gene, the probability of developing liver cirrhosis is 1.81 times higher (0.176–0.098, CI 95%,), in carriers of the rs4673 mutant allele of the CYBA gene, the probability of developing liver cirrhosis is higher by 1.9 times (0.211–0.111, CI 95%), in carriers of the mutant allele for the rs2070744 polymorphism of the NOS3 gene, the probability of developing liver cirrhosis is 2.03 times higher (0.181–0.089, CI 95%). Thus, the obtained results indicate the need for additional studies of these genes, since they can be predictors of the development of liver cirrhosis in patients with chronic viral hepatitis B in the Yakut population.
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