蛋白酶抑制剂对诱导动脉粥样硬化的老鼠心脏直肠炎症状的影响

Ilhami Romus, Ismawati Ismawati, Indah Putri Arwandi
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引用次数: 0

摘要

蛋白酶体抑制剂是能够抑制蛋白酶体途径发挥其功能的化合物。蛋白酶体抑制剂由于其抗炎特性而具有有益的作用。本研究中使用的蛋白酶体抑制剂是硼替佐米。本研究旨在分析蛋白酶体抑制剂对动脉粥样硬化大鼠心脏组织病理学的影响。本研究选用雄性褐家鼠Wistar品系,将其分为3组,即对照组、动脉粥样硬化诱导组和动脉粥样硬化诱导组,给予硼替佐米。结果显示,动脉粥样硬化组给予50 g/kgBW剂量的硼替佐米,其水肿、炎症和坏死的平均评分均低于动脉粥样硬化组。差异均有统计学意义(p<0.05)。本研究得出结论,硼替佐米可以减少动脉粥样硬化病变对心肌的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efek Inhibitor Proteasom Terhadap Gambaran Histopatologi Jantung pada Tikus yang diinduksi Aterosklerosis
Proteasome inhibitors are compounds that can inhibit the proteasome pathway in carrying out its functions. Proteasome inhibitors have a beneficial effect due to their anti-inflammatory properties. The proteasome inhibitor used in this study was bortezomib. This study aimed to analyze the effect of proteasome inhibitors on cardiac histopathology in atherosclerosis-induced rats. This study used male Rattus novergicus Wistar strain which was divided into 3 groups, namely the control group, the atherosclerosis-induced group and the atherosclerosis-induced group and given bortezomib. The results obtained the mean scores of edema, inflammation and necrosis in the atherosclerosis group were given bortezomib at a dose of 50 g/kgBW were less than the atherosclerosis group. Theese difference were statistically significant (p<0.05). This study concluded that the administration of bortezomib can reduce the Impact of atherosclerotic lesions on the heart muscle.
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