边缘活化剂:吐温80浓度变化对双氯芬酸钠扩散转移特性和速率的影响

Gabena Indrayani Dalimunthe, Ricky Andi Ayaputra
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引用次数: 1

摘要

双氯芬酸钠是一种由磷脂和边缘活化剂组成的透皮给药系统。Transfersom增加角质层脂质屏障毛孔的大小,然后通过跨屏障运动的驱动进入皮肤,并将自身挤压到脂质屏障毛孔的大小。本研究的目的是确定吐温-80浓度作为边缘活化剂对双氯芬酸钠转移特性和扩散速率的影响。采用涡声法制备了5种配方,分别为95:05、90:10、85:15、80:20和75:25,不同的磷脂酰胆碱浓度比。结果表明,这五种配方具有不同的形态。采用单因素方差分析的统计检验结果发现,边缘活化剂浓度对双氯芬酸钠转移的扩散速率有显著影响(p值)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Edge Activator: Effect of Concentration Variation of Tween 80 on Characteristics and Rate of Difusion transfersome sodium diclofenac
Diclofenac sodium is a Transfersom is a transdermal delivery system consisting of phospholipids and edge activators. Transfersom increases the size of the stratum corneum lipid barrier pores, then enters the skin through the drive of the trans-barrier motion and squeezes itself to follow the lipid barrier pore size. The purpose of this study is to determine the effect of the tween-80 concentration as an edge activator on the characteristics and diffusion rate of diclofenac sodium transfersom. Transferom preparation used the vortex-sonication method which was made in five formulae with variations in the concentration ratio of phosphatidylcholine and tween-80 (95:05, 90:10, 85:15, 80:20, and 75:25). The results show that all five formulae have different morphological forms. The results of statistical tests using One-Way ANOVA finds a significant effect (p-value) of the edge activator concentration on the diffusion rate of diclofenac sodium transfersom.
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