Prevalence of Helicobacter Pylori among different groups of Nephrotic children

Affifi M and Sharaf M-Ain Shams University Introduction : Gastritis and peptic ulcer are common in children with nephrotic syndrome (NS). This is because of immunospressive medications like steroids with proteinuria and subsequent hypoga mmeglobulinemia Aim of the work: Is to study the prevalence of H.pylori infection among different groups of children suffering from NS Subject and methods: This study was cross sectional-case controlled study conducted at pediatric nephrology clinic – Ain Shams University It was done between July 2019 till November 2020. It included 86 children with different types of N.S and 36 healthy age and sex matched children as control group. All N.S children had stool analysis for parasites and H.pylori antigen with renel functions. N.S children were divided into three groups according to the response to steroids Results :H.pylori infection is common in children with nephrotic than controls with a statistical signification difference (p<0.05) H.pylori infection is statistically signification correlated with GI symptoms as vomity,and infection with parasites besides duration of NS infection Conclusion: Stool antigen test is reliable test for detection of H.pylori infection .H.pylori infection is common in children with NS and related to GI complaints and parasitic infestations