{"title":"阿霉素金纳米杂化物对乳腺细胞抗肿瘤活性的提高","authors":"Amna H. Faid, Elham M. Mostafa, Marwa A Ramadan","doi":"10.21608/ijaecr.2023.212453.1000","DOIUrl":null,"url":null,"abstract":"The use of nanotechnology in medicine and definitely drug delivery allows the development of novel platforms for the efficient transport of drug molecules in diseased tissues. The current study aimed to use gold nanoparticles (GNPs) for Doxorubicin (Dox) drug carrier forming Dox/GNPs. Moreover, the cytotoxic effect was assessed on breast cancer cell line (MCF7) for different cultivation times. Dox/GNPs was examined by UV–visible spectroscopy, fluorescence spectroscopy and TEM. GNPs and Dox/GNPs have spherical and small size10±2 nm and 13±2 nm. The Anticancer Activity of the Dox/GNPs nanohybrid on the MCF7 cell line was increased compared to free Dox which indicate that AuNPs can be used as anticancer drug carrier for Doxorubicin in breast cancer treatment.","PeriodicalId":394406,"journal":{"name":"International Journal of Advances Engineering and Civil Research","volume":"1391 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Improved Anticancer Activity of Doxorubicin Gold Nanohybrid on Breast Cell Line\",\"authors\":\"Amna H. Faid, Elham M. Mostafa, Marwa A Ramadan\",\"doi\":\"10.21608/ijaecr.2023.212453.1000\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The use of nanotechnology in medicine and definitely drug delivery allows the development of novel platforms for the efficient transport of drug molecules in diseased tissues. The current study aimed to use gold nanoparticles (GNPs) for Doxorubicin (Dox) drug carrier forming Dox/GNPs. Moreover, the cytotoxic effect was assessed on breast cancer cell line (MCF7) for different cultivation times. Dox/GNPs was examined by UV–visible spectroscopy, fluorescence spectroscopy and TEM. GNPs and Dox/GNPs have spherical and small size10±2 nm and 13±2 nm. The Anticancer Activity of the Dox/GNPs nanohybrid on the MCF7 cell line was increased compared to free Dox which indicate that AuNPs can be used as anticancer drug carrier for Doxorubicin in breast cancer treatment.\",\"PeriodicalId\":394406,\"journal\":{\"name\":\"International Journal of Advances Engineering and Civil Research\",\"volume\":\"1391 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Advances Engineering and Civil Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21608/ijaecr.2023.212453.1000\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Advances Engineering and Civil Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/ijaecr.2023.212453.1000","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Improved Anticancer Activity of Doxorubicin Gold Nanohybrid on Breast Cell Line
The use of nanotechnology in medicine and definitely drug delivery allows the development of novel platforms for the efficient transport of drug molecules in diseased tissues. The current study aimed to use gold nanoparticles (GNPs) for Doxorubicin (Dox) drug carrier forming Dox/GNPs. Moreover, the cytotoxic effect was assessed on breast cancer cell line (MCF7) for different cultivation times. Dox/GNPs was examined by UV–visible spectroscopy, fluorescence spectroscopy and TEM. GNPs and Dox/GNPs have spherical and small size10±2 nm and 13±2 nm. The Anticancer Activity of the Dox/GNPs nanohybrid on the MCF7 cell line was increased compared to free Dox which indicate that AuNPs can be used as anticancer drug carrier for Doxorubicin in breast cancer treatment.
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