“表皮指数”测定对肝肾病理犬的诊断价值

O. P. Timoshenko, O. S. Snopenko, D. Kibkalo, M. Korenev, Y. Maslak
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摘要

Сondition毛发的变化反映了动物和人类在较长一段时间内的新陈代谢变化。因此,研究不同病理变异的家犬毛发,特别是肾病和肝肾多器官病理的家犬毛发,对于鉴别诊断和建立这些器官疾病发病机制中鲜为人知的环节是相关和适当的。本研究的目的是建立“表皮指数”对病犬的诊断意义。这项研究的对象是60只确诊的狗。采用一般临床方法(测定体温、脉搏、呼吸频率)对动物进行检查,并取颈静脉血液进行生化研究。获得毛发样本并测定“表皮指数”。对角质层的检查是在无色清漆上进行的,将其涂在玻片上,将头发压在清漆层上。然后,当清漆变硬时,将头发从外围端边缘去除。在显微镜下对印模进行了研究。X 400),并设置毛干最厚部分的根区“角质层指数”的值,以μm2表示。根据在临床和实验室研究中获得的结果,我们对病狗进行了分组,这成为研究“表皮指数”(CI)动态的基础。研究发现,在不同的肾病变异和犬的肝肾综合征和肾肝综合征的发展过程中,肝脏和肾脏发生了显著的结构变化,这与临床显微镜和生化血液检查结果确定的代谢过程的违反相对应,以及毛发角质层细胞外表面面积的变化,我们将其定义为“角质层指数”。测定“表皮指数”的方法可结合临床、仪器和实验室研究用于肾脏和肝脏病理的鉴别诊断,也可用于动物的药房检查。文章提供了各种病理变异的例子与定义“角质层指数”
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnostic value of "cuticular index" measuring in dogs with liver and kidney pathology
Сondition of hair reflects changes in metabolism in animals and humans in relatively long period of time. Thus, the study of hair of domestic dogs with different variants of pathology, in particular nephropathy and polyorgan pathology of liver and kidney is relevant and appropriate in terms of differential diagnosis and establishment of little-known links in the pathogenesis of diseases of these organs. The aim of this study was to establish the diagnostic meaning of «cuticular index» of sick dogs. The object of the study was 60 dogs with confirmed diagnoses. The animals were examined by general clinical methods (temperature, pulse, and respiratory rate were determined) and blood was taken from the jugular vein for biochemical research. Hair samples were obtained and the «cuticular index» was determined. Examination of the cuticle was performed using prints on a colorless varnish, which was applied to a glass slide, pressing the hair to the varnish layer. Then, when the varnish hardened, the hair was removed by the edge from the peripheral end. The impression was studied under a microscope (in. x 400) and set the value of «cuticular index» in the root zone, in the thickest part of the hair shaft, expressed in μm2. Based on the results obtained during clinical and laboratory studies, we have formed groups of sick dogs, which became the basis for studying the dynamics of the «cuticular index» (CI). It was found that in different variants of nephropathy and in the development of hepatic-renal and renal-hepatic syndromes in dogs, significant structural changes occur in the liver and kidney, which correspond to violations of metabolic processes determined by the results of clinical microscopic and biochemical blood tests, as well as changes in the area of the outer surface of the cells of hair cuticle, which we have defined as the «cuticular index». The method of determining the «cuticular index» can be used in differential diagnosis of kidney and liver pathology in combination with clinical, instrumental and laboratory studies, as well as for dispensary examination of animals. The article provides examples of various variants of pathology with the definition of «cuticular index»
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