细胞对超短、高强度电场反应的建模研究

2003 Annual Report Conference on Electrical Insulation and Dielectric Phenomena Pub Date : 2003-10-19 DOI:10.1109/CEIDP.2003.1254867

R. Joshi, Q. Hu, K. Schoenbach, V. Lakdawala

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引用次数: 14

摘要

基于电流连续性和Smoluchowski方程的耦合方案，研究了生物细胞在纳秒级高强度脉冲作用下的电穿孔动力学。提出了一种新的分布电流模型，该模型考虑了细胞膜和孔形成引起的亚结构的动态电导率。比较和讨论了正常和恶性(法拉奇)扁桃体b细胞的不同细胞反应。研究表明，超短、高强度的电脉冲可以选择性地破坏癌细胞。

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Modeling studies of cellular response to ultrashort, high-intensity electric fields

The dynamics of electroporation in biological cells subjected to nanosecond, high intensity pulses are studied based on a coupled scheme involving current continuity and Smoluchowski equations. A new distributed current model is presented for potential distribution to includes dynamic conductivities of cell membranes and substructures caused by pore formation. Different cell responses of normal and malignant (Farage) tonsillar B-cells are compared and discussed. It is shown that ultrashort, high-intensity electric pulses could selectively damage cancer cells.

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2003 Annual Report Conference on Electrical Insulation and Dielectric Phenomena

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