妊娠相关神经系统损伤的临床和实验室标志物的预后价值

Taitubaeva G.K., Gribacheva I.A., Popova T.F., Petrova E.V., Shchepankevich L.A., Denisova O.A.
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引用次数: 0

摘要

摘要目的:研究、整理和评价妊娠伴及不伴高血压(AH)的神经系统损害临床及实验室指标对脑卒中预后的意义,以确定发生脑卒中的主要危险因素。材料和方法。自主神经功能障碍评估,神经眼科检查,其他研究方法:实验室和仪器方法,包括基因多态性研究,CT, MRI结果。基于构建一组逻辑回归模型的结果,对高概率检测算法的结果进行概化,结果表明,为了确定孕妇发生缺血性卒中的最终高危人群,需要排除孕前无自主神经功能障碍的患者,并考虑至少在两个阶段检测到的风险。无论是否存在动脉高血压,脑病综合征、孕前自主神经功能障碍、避孕、合并3个以上病理单位、脑血管发育不全、神经眼科检查发现视网膜血管病变、纤维蛋白原水平升高、血管性血血病因子高活性等因素都是脑血管意外缺血性发展的常见危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
PROGNOSTIC VALUE OF CLINICAL AND LABORATORY MARKERS OF NERVOUS SYSTEM DAMAGE ASSOCIATED WITH PREGNANCY
Abstract. Objective: To study, to systematize and to evaluate the prognostic significance of clinical and laboratory markers of nervous system damage associated with pregnancy with and without arterial hypertension (AH) in order to determine the main risk factors for the development of stroke. Materials and methods. Assessment of autonomic dysfunction, neuro-ophthalmological examination, additional research methods: laboratory and instrumental methods, including the study of gene polymorphism, CT, MRI Results. Based on the results of constructing a set of logistic regression models that generalize their results of a high probability detection algorithm, it is shown that in order to identify the final group of high risk of developing ischemic stroke in pregnant women, it is necessary to exclude patients without autonomic dysfunction before pregnancy, and also take into account the risks if they are detected in at least two stages. Factors such as the presence of cephalgic syndrome, autonomic dysfunction before pregnancy, contraception, concomitant pathology of more than 3 nosological units, hypoplasia of cerebral vessels, retinal angiopathy according to neuro-ophthalmological examination, elevated levels of fibrinogen and high activity of von Willebrand factor are common risk factors for the development of cerebrovascular accident ischemic type, regardless of the presence or absence of arterial hypertension.
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