氧化应激环境中粉尘和辐射联合暴露的致癌和遗传毒性风险

L. Chulenbayeva, S. Kashanskiy, Kenzhekyz B. Manekenova, G. Ilderbayeva, Talgat M. Omarov, O. Ilderbayev
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引用次数: 0

摘要

在氧化应激背景下,长期受到6 Gy剂量煤尘联合辐射的大鼠出现细胞遗传学紊乱,支气管黏膜、肺间质动脉和小动脉壁发生改变,肝实质发生破坏性改变,肝小叶出现凝固坏死灶。研究结果表明,在氧化应激背景下,实验暴露于粉尘和辐射会增加动物的致癌和遗传毒性风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Carcinogenic and genotoxic risks of combined exposure to dust and radiation in oxidative stress environment
Rats subjected to coal dust combined with radiation dose of 6 Gy in long-term period demonstrated cytogenetic disorders and changes in bronchial mucosa, arterial and arterioli walls in lung stroma, destructive changes in liver parenchyma with colliquation necrosis foci in liver lobules, on oxidative stress background. Findings are that combined experimental exposure to dust and radiation on oxidative stress background increases carcinogenic and genotoxic risks in animals.
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