{"title":"青蒿治疗疟疾感染小鼠肾脂质、谷胱甘肽和丙二醛水平的比较研究","authors":"A. A. Akpovwehwee","doi":"10.5987/UJ-NJSE.17.126.1","DOIUrl":null,"url":null,"abstract":"The effect of aqueous extract of Aframomum sceptrum (spice) on the kidney of mice induced with malaria was assessed in this study. Six groups of six mice each were used: normal control, parasite control, normal + 250 mg of spice, parasite + 250 mg of spice, parasite+350 mg of spice and normal+350 mg of spice. After four days of treatment with aqueous extract of A. sceptrum, the mice were sacrificed and the kidneys collected to determine the levels of some biomarkers. The results revealed that the parasitized mice had a significant (p 0.05) alteration was observed in kidney level of reduced glutathione (GSH). It can be inferred that the antioxidants and bioactive metabolites of A. sceptrum are responsible for the observed change. Thus, A. sceptrum can play a crucial function in the management of malaria.","PeriodicalId":119603,"journal":{"name":"Nigerian Journal of Science and Environment","volume":"54 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2017-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"COMPARATIVE STUDY OF KIDNEY LIPID PROFILE, GLUTATHIONE AND MALONDIALDEHYDE LEVELS IN MALARIA INFECTED MICE TREATED WITH AFRAMOMUM SCEPTRUM\",\"authors\":\"A. A. Akpovwehwee\",\"doi\":\"10.5987/UJ-NJSE.17.126.1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The effect of aqueous extract of Aframomum sceptrum (spice) on the kidney of mice induced with malaria was assessed in this study. Six groups of six mice each were used: normal control, parasite control, normal + 250 mg of spice, parasite + 250 mg of spice, parasite+350 mg of spice and normal+350 mg of spice. After four days of treatment with aqueous extract of A. sceptrum, the mice were sacrificed and the kidneys collected to determine the levels of some biomarkers. The results revealed that the parasitized mice had a significant (p 0.05) alteration was observed in kidney level of reduced glutathione (GSH). It can be inferred that the antioxidants and bioactive metabolites of A. sceptrum are responsible for the observed change. Thus, A. sceptrum can play a crucial function in the management of malaria.\",\"PeriodicalId\":119603,\"journal\":{\"name\":\"Nigerian Journal of Science and Environment\",\"volume\":\"54 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-11-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nigerian Journal of Science and Environment\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5987/UJ-NJSE.17.126.1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nigerian Journal of Science and Environment","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5987/UJ-NJSE.17.126.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
COMPARATIVE STUDY OF KIDNEY LIPID PROFILE, GLUTATHIONE AND MALONDIALDEHYDE LEVELS IN MALARIA INFECTED MICE TREATED WITH AFRAMOMUM SCEPTRUM
The effect of aqueous extract of Aframomum sceptrum (spice) on the kidney of mice induced with malaria was assessed in this study. Six groups of six mice each were used: normal control, parasite control, normal + 250 mg of spice, parasite + 250 mg of spice, parasite+350 mg of spice and normal+350 mg of spice. After four days of treatment with aqueous extract of A. sceptrum, the mice were sacrificed and the kidneys collected to determine the levels of some biomarkers. The results revealed that the parasitized mice had a significant (p 0.05) alteration was observed in kidney level of reduced glutathione (GSH). It can be inferred that the antioxidants and bioactive metabolites of A. sceptrum are responsible for the observed change. Thus, A. sceptrum can play a crucial function in the management of malaria.
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