中国吉林省(白求恩医科大学)における非ホジキンリンパ腫の研究

A detailed histopathologic and immunohistochemical study has been carried out on primary extranodal non-Hodgkin's lymphoma (NHL), especially in gastrointestinal (GI) tract, and on primary intestinal and mesenteric lymph nodal lymphoma, comparatively. The material were collected from Jilin Provience, China. The results obtained were as follows:A total of 52 cases with extranodal NHL were consisted of 12 of stomach, 22 of intestine (16 of small intestine, 5 of ileocecum and 1 of cecum), 11 of Waldeyer's ring, and 7 of the others.Histologically, 45 cases were diffuse (D) type and the other 7 were follicular (F). D/F ratio was 6.4:1. Phenotypically, B/T ratio was 25:1.According to WF classification, the intermediate grade of malignancy was 43 cases (82.7%) including 24 cases (46.2%) of diffuse, large non-cleaved which was the most preponderant type.Five of 34 cases (14.7%) of primary GI lymphoma were reclassified as mocosa-associated lymphoid tissue (MALT) lymphoma. Three cases were composed of centrocyte-like (CCL) cells and the other 2 were of large blast-like cells. In all cases, the lymphoepithelial lesion (LEL) and reactive or neoplastic follicular structure were noted histologically, and positive finding of paranuclear dot for LN-1, both in CCL and blast-like cells, was found immunohistochemically.Two of 34 cases (5.9%) of primary GI lymphoma showed an appearance of multiple lymphomatous polyposis. The one was recognized as the results of dissemination of MALT lymphoma, because the LEL was distinctively exhibited and the medium-sized cell with nucleus showing marked cleavation. The other was identified as mantle zone lymphoma of multicentric origin, since the main component cells within the vague nodules were small and round nucleus with slight cleavation, negative for LN-1 and positive for LN-2, and no LEL was found.No evident association between the primary small intestinal and the primary mesenteric lymph nodal lymphoma had been recorded.