{"title":"健康男性志愿者2-n-丙基-2(E)-戊酸酯(δ 2(E)-丙戊酸酯)的单剂量耐受性和药代动力学","authors":"R H Düsing","doi":"10.1007/BF01962708","DOIUrl":null,"url":null,"abstract":"<p><p>2-n-Propyl-2(E)-pentenoic acid (delta 2(E)-valproate) was administered to healthy volunteers in oral doses of 50-800 mg. The drug was tolerated well and no significant adverse effects were observed. Pharmacokinetic parameters were determined. Valproate and 3-keto-valproate were detected as metabolites.</p>","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 3A","pages":"152-8"},"PeriodicalIF":0.0000,"publicationDate":"1992-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962708","citationCount":"3","resultStr":"{\"title\":\"Single-dose tolerance and pharmacokinetics of 2-n-propyl-2(E)-pentenoate (delta 2(E)-valproate) in healthy male volunteers.\",\"authors\":\"R H Düsing\",\"doi\":\"10.1007/BF01962708\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>2-n-Propyl-2(E)-pentenoic acid (delta 2(E)-valproate) was administered to healthy volunteers in oral doses of 50-800 mg. The drug was tolerated well and no significant adverse effects were observed. Pharmacokinetic parameters were determined. Valproate and 3-keto-valproate were detected as metabolites.</p>\",\"PeriodicalId\":19804,\"journal\":{\"name\":\"Pharmaceutisch weekblad. Scientific edition\",\"volume\":\"14 3A\",\"pages\":\"152-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-06-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/BF01962708\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmaceutisch weekblad. Scientific edition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/BF01962708\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutisch weekblad. Scientific edition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF01962708","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Single-dose tolerance and pharmacokinetics of 2-n-propyl-2(E)-pentenoate (delta 2(E)-valproate) in healthy male volunteers.
2-n-Propyl-2(E)-pentenoic acid (delta 2(E)-valproate) was administered to healthy volunteers in oral doses of 50-800 mg. The drug was tolerated well and no significant adverse effects were observed. Pharmacokinetic parameters were determined. Valproate and 3-keto-valproate were detected as metabolites.
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