T Saito, M Watanabe, Y Katamura, E Hashimoto, A Nabeshima, T Ashizawa, N Takahata
{"title":"酗酒者血小板腺苷酸环化酶活性","authors":"T Saito, M Watanabe, Y Katamura, E Hashimoto, A Nabeshima, T Ashizawa, N Takahata","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Platelet adenylate cyclase (AC) activity in the long-term abstinent alcoholics, who maintained abstinence from alcohol for at least one year was examined. Guanine nucleotide [Gpp(NH)p] stimulated AC activity was not changed in platelet membrane from long-term abstinent alcoholics. However, the extent of AC activity induced by 250 mM ethanol in vitro, in the presence of 1 microM Gpp(NH)p, was significantly reduced in platelet membrane from long-term abstinent alcoholics. These results suggest that platelet AC activity may be a biological marker for alcoholics.</p>","PeriodicalId":77015,"journal":{"name":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","volume":"27 6","pages":"623-8"},"PeriodicalIF":0.0000,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Platelet adenylate cyclase activity in alcoholics].\",\"authors\":\"T Saito, M Watanabe, Y Katamura, E Hashimoto, A Nabeshima, T Ashizawa, N Takahata\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Platelet adenylate cyclase (AC) activity in the long-term abstinent alcoholics, who maintained abstinence from alcohol for at least one year was examined. Guanine nucleotide [Gpp(NH)p] stimulated AC activity was not changed in platelet membrane from long-term abstinent alcoholics. However, the extent of AC activity induced by 250 mM ethanol in vitro, in the presence of 1 microM Gpp(NH)p, was significantly reduced in platelet membrane from long-term abstinent alcoholics. These results suggest that platelet AC activity may be a biological marker for alcoholics.</p>\",\"PeriodicalId\":77015,\"journal\":{\"name\":\"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence\",\"volume\":\"27 6\",\"pages\":\"623-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Platelet adenylate cyclase activity in alcoholics].
Platelet adenylate cyclase (AC) activity in the long-term abstinent alcoholics, who maintained abstinence from alcohol for at least one year was examined. Guanine nucleotide [Gpp(NH)p] stimulated AC activity was not changed in platelet membrane from long-term abstinent alcoholics. However, the extent of AC activity induced by 250 mM ethanol in vitro, in the presence of 1 microM Gpp(NH)p, was significantly reduced in platelet membrane from long-term abstinent alcoholics. These results suggest that platelet AC activity may be a biological marker for alcoholics.
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