铁动力学研究评价某些临床情况下红细胞生成和储存铁成分的变化。

M M Gupta, P Roth, E Werner
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引用次数: 1

摘要

本文描述了一种用于铁动力学研究中59Fe活度在体内器官测量的定量分析方法。通过对骶骨、肝脏和脾脏的连续表面监测获得的时间-活性曲线可以定量地分解为它们的不同组成部分,从而记录计数率。分析分三个步骤进行:(1)校正来自其他器官的活动和来自被调查器官以外区域的散射辐射的计数率贡献。(2)将组织吸收的放射性与灌注血液中所含的放射性加以区分。(3)通过使用计算机程序(SAAM-27)并假设内部铁交换的室室模型,由此产生的净器官活性进一步分解为红细胞生成和储存铁成分。该方法在三组不同血液病患者和正常对照中进行了试验。在不同的疾病中发现了参数的特征模式,结果与临床表现有很好的相关性。结论是,体内59Fe活性的器官测量,当进行和分析足够小心时,可以提供对器官中发生的铁交换动力学的洞察。这种分析方法可以提高铁动力学研究的诊断预测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Changes of erythropoietic and storage iron components in certain clinical situations as evaluated by ferrokinetic investigations.

A method is described for the quantitative analysis of in vivo organ measurements of 59Fe activity in ferrokinetic investigations. The time-activity curves obtained by sequential surface monitoring over sacrum, liver and spleen can be resolved quantitatively into their different components contributing to the recorded count rate. The analysis is performed in three steps: (1) Count rate contributions from activity in other organs and from scattered radiation from regions outside the organ under investigation are corrected. (2) Distinction is made between radioactivity uptake of the tissue and radioactivity contained in the perfusing blood. (3) The resulting net organ activity is then further resolved into an erythropoietic and a storage iron component by use of a computer program (SAAM-27) and assuming a compartmental model for internal iron exchange. The method was tested in three groups of patients with different haematological disorders and in normal controls. Characteristic patterns of the parameters are found for different diseases and the results correlated well with the clinical findings. It is concluded that in vivo organ measurements of 59Fe activity, when performed and analysed with sufficient care, can provide an insight into the dynamics of the iron exchange that is taking place in an organ. This analytical approach may improve the diagnostic predictions of ferrokinetic investigations.

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